Caffeine and its major metabolites; Theobromine, Theophylline and Paraxanthine are routinely monitored by anti-doping agencies as potential performance enhancers. Similar precursors and product ions of Theophylline and Paraxanthine makes the LCMS analysis of this panel very challenging. The aim of the study was to develop an efficient extraction and analysis method for caffeine and metabolites…
A new study led by researchers at Oklahoma State University focuses on a better understanding of the pharmacokinetics of orally administered cannabidiol in horses. With the growing popularity of cannabidiol products in the equine industry, it becomes necessary to comprehend the efficacy and pharmacology of such drugs. A low and a high dose of CBD…
Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for infectious agents. However, current approaches for identifying neutralizing Abs (nAbs) typically rely on dilution-based assays that are costly, inefficient, and only survey a small subset of the entire repertoire. In a recent paper authored Jose A….
UCT is excited to again participate in Emerald Conference 2020. Our regional representative Debby Miller along with our Technical Specialist, Melissa Chandler will be present all show to meet with current and prospective customers. Product headlines for 2020 include our rugged Selectra® C18 Column and corresponding method for a simple and robust method for the…
Ready for another year of Pittcon in Chicago. UCT Domestic and International Sales Representatives will be available during the show to meet with customers and field questions. We are beyond excited to be featuring our all new booth display along with new products to include SPeVAP, our 32 and 48 Position Multi-function Solvent Evaporator along…
UCT’s long chain C30 SPE was employed to analyze drugs in bottlefly larvae. The research aimed to determine whether varying concentrations of warfarin impacts the development of blue bottlefly larvae and to determine whether warfarin levels in this organism can be correlated to drug concentrations in tissues eaten by the larvae. This research was presented by Richard L. Harries et al., at the UKIAFT annual meeting in Dublin.
In a recent paper authored by Lia D. Murty et al., published in Journal of Agricultural and Food Chemistry (DOI: 10.1021/acs.jafc.8b00963), UCT’s Clean Up® solid phase extraction silica was employed in the study of co-exposure of the mycotoxins Lolitrem B and Ergovaline in steers fed perennial ryegrass (Lolium perenne) straw. Past research showed a strong linear correlation between levels of the two mycotoxins in ryegrass.
Haloxyfop is a selective herbicide that is used to protect crops such as potatoes and carrots against persistent grasses. In a recent paper authored by Urairat Koesukwiwat et al., (Analytical and Bioanalytical Chemistry https://doi.org/10.1007/s0021), the authors developed and validated a simple method for total haloxyfop analysis in infant formula and related ingredient matrices using UCT’s QuEChERS and liquid chromatography-tandem mass spectrometry (LC-MS/MS).
The determination of original source of use-related residues on prehistoric stone tools is especially challenging, due to issues related to preservation, contamination and multiple source residue the contributions. To increase confidence in this process, an analytical workflow was developed by Susan Luoing et al., published in Analytical Methods (2017, 9, 4349) which included a sampling strategy that retains spatial information of the recovered residues and enables monitoring of environmental contamination; and a sensitive and selective gas chromatography-tandem mass spectrometry (GC-MS/ MS) procedure to quantify non-volatile low molecular weight lipids on stone artefacts. Representative aliquots were spiked with internal standards. After extraction of the lipids and evaporation of the extracts, the samples were derivatized with UCT’s MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide) containing 1%TCMS (1% trimethylchlorosilane) silylation reagent.
Driving under the influence of drugs (DUID) has become a growing issue nationwide and likewise in Orange County (OC), California. In research published in Journal of Forensic Sciences by K. Declues et al., UCT’s famous Clean Screen® THC SPE cartridges were used to extract cannabinoids from samples of whole blood taken from apprehended drivers in OC over a two-year period. In this study (Part II of a two stage study), a comparison was conducted of examined objective signs, eye examinations and physiological indicators with their relationship to the presence of identified concentrations of THC.
In the field of animal sports toxicology, UCT is recognized around the world as the premier manufacturer of the finest sorbents for the extraction of steroids and other doping agents in equine urine. In a recent paper published in Journal of Pharmaceutical and Biomedical Analysis by H.D.Shin et al., (doi= 10.1016/j.jpba.2017.06.036) a high throughput method for simultaneous screening of anabolic steroids and their metabolites (4-esterendione, trenbolone, boldenone, oxandrolone, nandrolone, methandrostenolone, testosterone, 1-androstendione, ethisterone, normethandrolone, methyltestosterone, 16β-Hydroxystanozolol, epitestosterone, bolasterone, norethandrolone, danazol, stanozolol and androstadienone) in equine urine was developed using UCT’s large particle Xtrackt® SPE sorbent (XRDAH203).
UCT is known in the industry as the premier manufacturer of Solid Phase Extraction (SPE) sorbents. Many of these clean-up products are commonly utilized in the food safety and public protection markets, for example in the detection of Ractopamine (RAC) in animal feed. RAC is a phenylethanolamine that has been approved for use as a feed additive in some countries to enhance leanness in animal selected species. It is used with the purpose of increasing the rate of weight gain, improving feed efficiency and increasing carcass leanness. Despite these benefits, the use of RAC has been related to adverse effects in cardiovascular and central nervous systems of animals and consumers. In a paper authored by Caldeira et al., published in the journal Accreditation and Quality Assurance ((2017) 22,91–96), an analytical method was developed and validated based on extracting RAC with acetate buffer, hydrolyzing with β-glucuronidase and a purifying by SPE using UCT’s world renowned flagship SPE sorbent Clean Screen® DAU.
The ability to separate complex mixtures of structurally similar compounds within one method is highly desirable. Additionally, compounds of related structures may also be isobaric with similar fragmentation, rendering them unidentifiable by MS/MS. In these cases, it is essential that these compounds be baseline separated chromatographically.
UCT is well recognized in the analytical testing field for manufactoring the finest silica and polymeric based sorbents. Most recently, The Styre Screen ® SPE column line has been utilized in a paper authored by R.C. Kevin et al., (University of Sydney, Australia) in the journal Forensic Toxicology (doi:10.1007/s11419-016-0330-0) where urinary cannabinoid concentrations were measured during nabiximols (Sativex®)-medicated inpatient cannabis withdrawal. The hydrolysed samples containing (CBD, THC, THC-COOH, and 11-OH-THC) were directly loaded onto Styre Screen® (SSTHC063) SPE columns. This paper demonstrates the efficiency of UCT’s polymeric Styre Screen® sorbents in the analysis of cannabinoids, and why researchers working in the field of cannabinoid analysis turn first to UCT for the finest in silica and polymeric sorbents.
One of the most difficult challenges facing forensic toxicologists is the extraction, analysis and quantification of synthetic cathinones. In a paper published in Journal of Analytical Toxicology (JAT) by Peters et al., from East Tennessee University (doi: 10.1093/jat/bkw074), UCT’s flagship SPE Clean Screen® DAU was employed to extract the bathsalts from rat brain tissue. This article demonstrates the power of the Clean Screen®DAU to assist forensic toxicologists in efficiently extracting newer psychoactive compounds from very complex matrices.
Amphetamine-type stimulants, including methamphetamine, are the world’s second most commonly used illicit drug (surpassed only by marijuana), with at least 30 million people using it regularly. In a recent paper published by D.V.Vaupel et al working with the scientists at National Institute of Drug Abuse (NIDA), UCT’s flagship sorbent Clean Screen® DAU (ZSDAU020) was employed to extract and analyze methamphetamine from the whole blood of eight male rhesus monkeys to gain a better toxilogical understanding of the long-term effects of these compounds.
UCT, Inc has seen tremendous growth internationally over the past decade. As part of efforts to better serve its channel partners and customers, UCT began exploring opportunities to expand its physical presence internationally.
No products in the cart.