One of the most difficult challenges facing forensic toxicologists is the extraction, analysis and quantification of synthetic cathinones. The abuse of synthetic cathinones, formerly marketed as “bath salts”, has increased over the last decade. Three common drugs in this class include 3,4-methylenedioxypyrovalerone (MDPV), 4-methylmethcathinone (mephedrone), and 3,4-methylenedioxymethcathinone (methylone). Analysts working with complex matrices such as brain tissues require an extraction method that can produce extracts that are not only clean but highly reproducible. In a paper published in Journal of Analytical Toxicology (JAT) by Peters et al., from East Tennessee University (doi: 10.1093/jat/bkw074), UCT’s flagship SPE Clean Screen® DAU was employed to extract the bathsalts from rat brain tissue. Briefly, MDPV, mephedrone, methylone, and their deuterium-labeled analogs were subjected to SPE (Clean Screen DAU) and analyzed by LC-MS/MS. This article demonstrates the power of the Clean Screen®DAU to assist forensic toxicologists in efficiently extracting newer psychoactive compounds from very complex matrices.