Gallium-68 (68Ga, t1/2 ¼ 67.8 min) owns great potential in nuclear medicine being extensively used in labelling of biomolecules like somatostatin and PSMA inhibitor analogues. 68Ga decay to stable Zinc-68 (68Zn) nuclide via electron capture (11%) and positron decay (89%) and is generally produced via 68Ge/68Ga generators. Although this approach is widely used, the generators are expensive, and they deliver limited activity per elution with restrictive waiting time between elution. An alternative method to produce 68Ga is by cyclotron using high enriched 68Zn via the 68Ga(p,n)68Zn reaction. The cross-section values and thick target yields using 68Zn target below 24 MeV proton energy were evaluated by many groups and the data are very consistent.
In a recent paper published in Applied Radiation and Isotopes ((2020) 156 109014) authored by Aiman H. Alnahwi et al., UCT’s Clean Up solid phase extraction (SPE) cartridges (CUBCX123) were employed in a study into the automated radiosynthesis of 68Ga for large-scale routine production using 68Zn pressed target. The objectives of this study were to develop a fast and efficient process for the preparation of 68Zn based solid targets and to optimize the critical parameters for the automated radiosynthesis of [68Ga]GaCl3 for large-scale routine production
When scientists working in the field of nuclear medicine require the finest of solid phase extraction sorbents for their investigations, they look to UCT as their first choice for materials. For more information regarding UCT Clean Up® sorbents, visit www.unitedchem.com.