UCT Clean Screen DAU cited in Postmortem Toxicology Article

February 24th, 2020 Sample Preparation News

The United Nations Office on Drugs and Crime (UNODC) estimated that 76% of drug related fatalities during 2016 were related to the misuse of opioids. The UNODC also reported that the production of opium and cocaine are at the highest levels ever recorded, with the distribution of methamphetamine and cocaine expanding to new regions. The same report indicated that among individual between the ages of 14 and 65 years, 192 million used cannabis, 34 million used opioids, 19 million used opiates, 34 million used amphetamine and prescription stimulants, 21 million used ecstasy, and 12 million used cocaine at least once during 2016, which Journal Pre-proof is meaning that the abuse of traditionally abused drugs remains stable and represent major causes of death.

In a recent paper authored by A. I. Alasmari, published in Forensic Science International (DOI: https://doi.org/10.1016/j.forsciint.2020.110193), UCT’s famous solid phase extraction (SPE) sorbent (CSDAU203) was integral for the identification and quantification of 60  drugs and their metabolites in postmortem whole blood using SPE and  liquid chromatography tandem mass spectrometry (LC-MS/MS). The aim of the study was to develop and validate a method for the detection of sixty drugs and metabolites that are most commonly encountered in postmortem whole blood.

All calibration curves were found to be linear with coefficients of determination greater than 0.99. The limits of detection ranged from 0.2 ng per mL to 1.0 ng per mL and the limits of quantification range from 1.0 ng per mL to 5.0 ng per mL . Matrix effects ranged from -15% to +22%. After excluding matrix effects, analytical recoveries ranged from 76% to 100%.

This study presents a SPE method using the power of the Clean Screen® DAU, the most robust sorbent in the marketplace. For more information regarding Clean Screen SPE products, visit https://www.unitedchem.com/product/clean-screen-dau/

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