Top 10 Forensic Compounds/Topics of 2016 – Enzyme Hydrolysis Rates for Opiates

December 21st, 2016 Sample Preparation News

The hydrolysis of morphine-3-glucuronide and various other conjugated drug classes such as benzodiazepines and synthetic cannabinoids is routinely fast and efficient. Other compounds prove to be more difficult to covert, such as codeine-6-glucuronide, due to the nature of the chemical bonds at hand and the configuration of the enzyme to the substrate.  Derived from red abalone, UCT’s Abalonase™ requires as little as 5,000 activity units per milliliter of sample in order to achieve conversion rates of over 80% for both morphine-6-glucuronide and codeine-6-glucuronide.  This purified and clear enzyme reduces average hydrolysis time when compared to traditional formulations while keeping cost per sample down thanks to less activity units needed when comparing to other purified products in the market.

Add a Comment

You must be logged in to post a comment.