Incorporation of Clean Screen FASt® extraction in the study of ZCZ-011 in mouse brain tissue helps minimize and stabilize matrix ion suppression effects

http://www.chromatographyonline.com/determination-cannabinoid-content-and-pesticide-residues-cannabis-edibles-and-beverages

Researchers at the Republic of Korea National Forensic Service have recently published an article in the journal of the Japanese Association of Forensic Toxicology titled ‘Simultaneous quantification of 37 synthetic cannabinoid metabolites in human urine by liquid chromatography-tandem mass spectrometry’ (doi 10.1007/s11419-015-0265-x).

Numerous polymerase-chain-reaction (PCR) and isothermal amplification methods employed currently in molecular diagnostic assays have been developed, significantly improving assay sensitivity and specificity as well as shortening overall time. In spite of this objective, nucleic acid target amplification continues to present challenges for dealing with “false-positive” results due to environmental or reagent contaminants introduced during the testing process. This has been addressed in a recent article authored by Wanyuan Ao et al., published in PLoS ONE 12(2): e0171915 in which UCT silane amine-functional T-structure polydimethylsiloxane (TSPS) was described in the production of crystalline silicon wafers. In this paper, the authors describe a strategy that can distinguish between staphylococcus species truly present in a clinical sample from contaminating staphylococcus species introduced during the testing process.

Researchers at the National Institute on Drug Abuse (NIDA), led by Marilyn Huestis, PhD, have recently published an article in the journal Drug Testing and Analysis titled ‘Quantification of six cannabinoid metabolites in oral fluids by liquid chromatography-tandem mass spectrometry’ (doi 10.1002/dta1753).