UCT application chemist, Dr. Xiaoyan Wang, is presenting a poster on the use of QuEChERS as a novel extraction technique for the determination of benzodiazepines and steroids in whole blood. In clinical laboratories, the commonly used sample preparation techniques include immunoassay, liquid-liquid extraction (LLE) and solid phase extraction (SPE). QuEChERS (acronym for Quick, Easy, Cheap, Effective, Rugged and Safe) is a novel sample preparation technique that was originally reported by the scientists at the USDA in 2003 for the determination of multi-class pesticide residues in fruits and vegetables. Since then, QuEChERS has been adopted quickly and widely to determine various analytes of interest in different matrices, such as veterinary drugs in animal tissues, mycotoxins in grains, polycyclic aromatic hydrocarbons in seafood, bisphenol A in canned foods and beverages, and cannabinoids in medical marijuana and cannabis foods. In this study, QuEChERS methodology will be applied for the analysis of clinical therapeutic drugs, such as benzodiazepines and anabolic steroids in whole blood.