Endcapped C18 Helps Researchers Achieve Excellent Analyte Sensitivity and Recovery for 131 Drug Residues in Bovine Muscle

ByUCT

The article, titled “Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry” (DOI: 10.1007/s00216-014-8386-3) uses a d-SPE technique for the extraction of 131 veterinary drug residues in bovine muscle samples.

The extraction sorbent used was a UCT endcapped C18. In the article the authors stress the increasing importance of multiclass, multiresidue methods in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency.

The validated method provided excellent sensitivity for drug compounds from 13 different classes and resulted in analyte recoveries ranging from 70-120%.  UCT’s sorbent plays a key role in cleaning up the tissue extracts while still providing excellent analyte recoveries.

Similar Posts

UCT XtrackT® Solid Phase Extraction Sorbent Cited in Environmental Analysis Article

UCT XtrackT® Solid Phase Extraction Sorbent Cited in Environmental Analysis Article

ByUCT

UCT’s XtrackT® solid phase extraction sorbent (XRDAH506) was employed in a validated method to isolate several illicit drugs from urban waste water samples in South Australia. The occurrence of five drugs of abuse in raw influent and treated effluent wastewater was investigated over a period of 1 year in Adelaide. Results showed that all the targeted drugs were on average incompletely removed by wastewater treatment, with removal performance highest for morphine (94%) and lowest for MDMA (58%). 

Fentanyl Overdose Analysis Executed on UCT SPE Column

ByUCT

There have been 256 fatal overdoses from illicit drugs in the first four months of this year in Canada, already more than half the 480 that occurred for all of 2015. Fentanyl’s connection to those deaths has been surging at a staggering rate. As a standard basic drug with a pKa of 8.8, fentanyl is a prime candidate for strong cation exchange SPE on such sorbents as UCT’s flagship cartridge Clean Screen® DAU. Fentanyl’s main metabolite, norfentanyl, and its newer analogs such as acetylfentanyl are also favored by this sorbent and corresponding methodology for high quality results.

UCT FASt THC Cartridges Cited in Analyzing Beverages for Cannabinoids

UCT FASt THC Cartridges Cited in Analyzing Beverages for Cannabinoids

ByUCT

In the past decade, use of cannabinoids in the United States has increased tremendously. This increase has been primarily in marijuana-infused products, initially as food products and now as beverages. The three most common beverage matrices involve fermented (beer/ale), brewed (tea/coffee), and high sugar (soft drinks). Each of these matrices creates its own analytical challenges….

Check Out UCT’s New Cannabis Technical Article ‘Determination of Cannabinoid Content and Pesticide Residues in Cannabis Edibles and Beverages’ on LCGC!

Check Out UCT’s New Cannabis Technical Article ‘Determination of Cannabinoid Content and Pesticide Residues in Cannabis Edibles and Beverages’ on LCGC!

ByUCT

http://www.chromatographyonline.com/determination-cannabinoid-content-and-pesticide-residues-cannabis-edibles-and-beverages

UCT Clean Screen® DAU Cited in Novel Fentalogs Article

UCT Clean Screen® DAU Cited in Novel Fentalogs Article

ByUCT

Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. They both have been reported by the Drug Enforcement Administration in their third quarter report of 2017 to have been chemically identified seven and five times, respectively. In a recent paper authored by Melissa F. Fogarty et al., published in Journal of Analytical Toxicology (doi: 10.1093/jat/bky035), an analytical method was developed and validated to extract fentalogs from whole blood samples using UCT’s Clean Screen ® DAU. The method used LC-MS/MS for the quantitation of fentanyl, norfentanyl and 17 fentanyl analogs. 

UCT Clean Screen® DAU columns cited in Pharmacology Paper

UCT Clean Screen® DAU columns cited in Pharmacology Paper

ByUCT

UCT is known around the world for its support of clinical pharmacologists and their studies as they look for the finest sorbents to perform the extractions.  In a recent paper by Adam L. Halberstadt  (Department of Psychiatry, University of California San Diego), UCT’s flagship sorbent Clean Screen® DAU (ZSDAU020) was employed in the study involving the interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine (Pharmacology, Biochemistry and Behavior (2016) 143 1–10).Monoamine oxidase inhibitors (MAOIs) are often ingested together with tryptamine hallucinogens, but relatively little is known about the consequences of their combined use.

Leave a Reply