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UCT Flagship Sorbent Clean Screen® Cited in Synthetic Cathinones Study
In recent years, the abuse of newer psychoactive substances (NPS) such as synthetic cathinones or ‘bath salts’ has become a major public health concern. These compounds were initially sold legally and labeled “not for human consumption.” Three popular drugs of this type are methylone, mephedrone, and 3, 4-methylenedioxypyrovalerone (MDPV). Unfortunately, there is currently no information available on the teratogenicity of these compounds, or of the extent to which they cross the placenta. In a recent paper authored by Lauren G. Strange et al., published in the journal Neurotoxicology and Teratology ((2017) 63 9–13) this issue was addressed by employing UCT’s flagship sorbent Clean Screen® DAU followed by analysis utilizing HILIC LC-MS/MS. The purpose of this study was to examine the pharmacokinetic profile of the ‘bath salts’ in a pregnancy model using an animal model.
Analyzing pesticides and metal(loid)s in imported tobacco to Saudi Arabia and risk assessment of inhalation exposure to certain metals
Researchers at the Reference Laboratory for Food Chemistry, Saudi Food & Drug Authority (SFDA), Riyadh, Saudi Arabia, have discovered more toxins in cigarettes than previously thought. The researchers analyzed 60 tobacco samples from 8 popular cigarettes brands commercially available in the Saudi market. They found significant concentrations of toxic metals and banned pesticides. The researchers…
UCT Flagship Sorbent Clean Screen® DAU cited in Novel Psychoactive Substance (NPS) Study
The analysis of hair provides forensic toxicologists with several significant benefits in casework. Not only is it utilized when more conventional matrices such as blood and urine are not available, but also it provides an approximate timeline of drug use. Hair analysis is particularly useful in cases of child custody, workplace drug testing or in drug facilitated sexual assault cases. In a new paper authored by Lorna A Nesbit et al., published in Journal of Analytical Toxicology (doi: 10.1093/jat/bkx053) a group of NPS compounds (25B-, 25C- and 4-iodo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine) and 25I-NBOMe, using 4-bromo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25B-NBOMe)-D3, were analyzed using UCT’s flagship SPE sorbent Clean Screen® DAU (CSDAU133).
The Use of ZSTHC020 in German Cannabinoids Study
Of all the analytes that Forensic Toxicologists are asked to test for, THC still remains high on the list. In this recent study published in the International Journal of Legal Medicine (DOI 10.1007/s00414-016-1368-6) from the Institute of Legal Medicine (Muenster, Germany), a procedure employing UCT’s Flagship THC SPE column (ZSTHC020) was developed and validated for analysis of cannabinoids.
UCT Clean Screen® DAU Cited in Novel Fentalogs Article
Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. They both have been reported by the Drug Enforcement Administration in their third quarter report of 2017 to have been chemically identified seven and five times, respectively. In a recent paper authored by Melissa F. Fogarty et al., published in Journal of Analytical Toxicology (doi: 10.1093/jat/bky035), an analytical method was developed and validated to extract fentalogs from whole blood samples using UCT’s Clean Screen ® DAU. The method used LC-MS/MS for the quantitation of fentanyl, norfentanyl and 17 fentanyl analogs.
Development and Validation of a Multi-drug Analysis for Hair
A single sample preparation and instrument method was developed for the analysis of 54 analytes in hair. Analytes in the panel included drug of abuse, synthetic opioids, and ethyl glucuronide. Hair is an alternative matrix used in forensic toxicology due to its longer detection window. The matrix is also more stable, does not require refrigerated…