Optimization of NPS sample preparation in blood, urine, serum, and plasma
New/Novel Psychoactive Substances (NPSs) are newly emerging, rapidly developing compounds designed to mimic the intoxicating effects of illicit substances. The ever-changing landscape of the NPS market and the varying physiochemical properties of these compounds make developing and validating up-to-date analytical methods a challenge. Different extraction and derivatization procedures were assessed to determine an optimal procedure…