Drug trends in some regions of the world are extensively studied while in other regions little to no research has been done. For example, countless studies have been performed in Read More
Drug trends in some regions of the world are extensively studied while in other regions little to no research has been done. For example, countless studies have been performed in Read More
Fentanyl serves as a powerful analgesic agent to manage pain during labor and delivery. However, prolonged prenatal exposure can make babies drug dependent and sudden discontinuation may result in conditions Read More
In a recent article published in the MDPI journal, authored by Ahmed I. Al-Asmari et al., UCT’s Clean Screen® DAU column (CSDAU203) was employed to extract Amphetamines from cadaveric fluids. Read More
The main aims of postmortem toxicological analysis are to determine the presence of possible substances in the corpses and their role in the cause of death. For that, conventional matrices Read More
Carfentanil (methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidine-4- carboxylate) is the most potent opioid used commercially with a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl. The drug is Read More
The United Nations Office on Drugs and Crime (UNODC) estimated that 76% of drug related fatalities during 2016 were related to the misuse of opioids. The UNODC also reported that Read More
In a recent paper published in Journal of Analytical Toxicology (doi: 10.1093/jat/bky077), authored by Mohammad Ali Al Saad et al., UCT’s Clean Screen®DAU was employed to extract opiates from whole blood. This method was validated for the simultaneous determination of codeine, morphine, 6-acetylmorphine (6-MAM), hydrocodone and hydromorphone in human blood samples
UCT’s famous Clean Screen® DAU was used to extract fentanyl and 18 additional compounds from whole blood samples. A fit-for-purpose method validation adapted from SWGTOX was performed by assessing the following criteria over five days: bias, precision, linear dynamic range, interferences and carryover.
In a recent study by Guillermo Alberto Keller et al., published in Journal of Opioid Management , UCT’s Clean Screen® DAU was used to extract Propoxyphene (DPX) and norpropoxyphene (NPX) from human plasma and analyzed by GC-MS. Plasma samples (500 µl) were treated with a strong alkali hydroxide to form NPX amide and extracted using CSDAU203. The recovery of the procedure was higher than 81%.
In a recent study authored by Ibraheem M. Attafi et al., published in the Arab Journal of Forensic Sciences & Forensic Medicine ((2018) 7(1) 922-930)), a postmortem case report aimed to identify and determine the concentration of cathine and cathinone in different body organs and green chewed plants found in the mouth of the deceased. Extraction of the khat compounds was performed using UCT’s Clean Screen® DAU in conjunction with LC-MS/MS quantitative analysis to confirm that samples were positive for cathinone and cathine.