Clean Screen

Optimization of NPS sample preparation in blood, urine, serum, and plasma

Optimization of NPS sample preparation in blood, urine, serum, and plasma

ByUCT

New/Novel Psychoactive Substances (NPSs) are newly emerging, rapidly developing compounds designed to mimic the intoxicating effects of illicit substances. The ever-changing landscape of the NPS market and the varying physiochemical properties of these compounds make developing and validating up-to-date analytical methods a challenge. Different extraction and derivatization procedures were assessed to determine an optimal procedure…

TBI uses forensic intelligence from the forensic drug chemistry unit to implement nitazene screening method in the forensic toxicology unit

TBI uses forensic intelligence from the forensic drug chemistry unit to implement nitazene screening method in the forensic toxicology unit

ByUCT

Tennessee’s Bureau of Investigation (TBI) forensic drug chemistry unit confirmed its first case with nitazenes in late 2019. From January 2021 to December 2023 the forensic drug chemistry unit reported 344 cases positive for nitazenes. 227 of these cases (66%) reported one or more additional drugs in the sample, fentanyl and heroin were the most…

Clean Screen® DAU Featured in Method to Analyze Xylazine, p-Fluorofentanyl, Fentanyl, and Fentanyl-Related Compounds in Postmortem Blood
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Clean Screen® DAU Featured in Method to Analyze Xylazine, p-Fluorofentanyl, Fentanyl, and Fentanyl-Related Compounds in Postmortem Blood

ByUCT

The presence of xylazine continues to be on the rise in samples containing fentanyl or fentanyl-related substances. A recent method published in the Journal of Chromatography B uses SPE and LC/MS-MS to quantitate xylazine, 4-ANPP, acetyl fentanyl, fentanyl, norfentanyl, and p-fluorofentanyl. Xylazine is rarely abused on its own, and research suggests it has effects comparable…

UCT Clean Screen EtG Sorbent Cited in Nerve Agent Article

UCT Clean Screen EtG Sorbent Cited in Nerve Agent Article

ByUCT

The use of chemical weapon nerve agents is banned by international convention and widely considered a human rights violation. Nonetheless, nerve agents have been used in attacks on military personnel and civilians in Iraq, Japan, Malaysia, Britain and Syria. For forensic and judicial purposes, verification of nerve agent exposure from biomatrices is needed to unambiguously…

Incorporation of Clean Screen FASt® extraction in the study of ZCZ-011 in mouse brain tissue helps minimize and stabilize matrix ion suppression effects

Incorporation of Clean Screen FASt® extraction in the study of ZCZ-011 in mouse brain tissue helps minimize and stabilize matrix ion suppression effects

ByUCT

Researchers at the Virginia Commonwealth University (Richmond, VA, USA), University of Aberdeen (Aberdeen, U.K.) and the University of Toronto (Toronto, Canada) have developed a novel pharmacological tool for the investigation of the cannabinoid receptor in mouse brain tissue using HPLC-MS-MS analysis.