Mushrooms for Memory?

Researchers worldwide have been studying Hericium erinaceus [1] (also called lion’s mane mushroom, mountain-priest mushroom, or bearded tooth fungus). This magical mushroom is common throughout North America, Europe, and Asia and can be seen growing on dead American beech and maple trees in late summer and autumn.

Most research involves testing how various compounds extracted from the mushroom affect hippocampal and cerebellar neurogenesis. [2] Researchers used multiple solvents at different polarities to extract the neurogenic compounds. The neurogenic compounds include N-de(phenylethyl)isohericerin (NDPIH), Hericene A, Corallocin A, Hericenone C, Hericenone D, and 4-[30,70-Dimethyl-20,60-octadienyl]-2-formyl-3-hydroxy-5 methoxy benzyl alcohol [3] (see figure 1 below).

These studies indicate that some of the bioactive components found in H. erinaceous promote neuritogenesis and are a possible candidate for therapy to prevent, reduce or treat age-related neural degeneration of memory or treatment for dementia and Alzheimer’s. Please consult your health care professional before using any nutraceutical products, and purchase all edibles from a reliable source.

Take a look at our website to view our many extraction, purification, and LC analysis products. If you don’t know where to start, UCT customers always benefit from our expert technical support and outstanding customer service.

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References:

1. Hericium erinaceus. (2023, 10 February). In Wikipedia. https://en.wikipedia.org/wiki/Hericium_erinaceus
2. Ratto, Daniela & Corana, Federica & Mannucci, Barbara & Priori, Erica & Cobelli, Filippo & Roda, Elisa & Ferrari, Beatrice & Occhinegro, Alessandra & di Iorio, Carmine & De Luca, Fabrizio & Cesaroni, Valentina & Girometta, Carolina & Bottone, Maria & Savino, Elena & Kawagishi, Hirokazu & Rossi, Paola. (2019). Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients. 11. 715. 10.3390/nu11040715.
3. Martínez-Mármol, R., Chai, Y.,Conroy, J. N., Khan, Z., Hong, S.-M., Kim, S. B., Gormal, R. S.,Lee, D. H., Lee, J. K., Coulson, E. J., Lee, M. K., Kim, S. Y., & Meunier, F. A. (2023). Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory Journal of Neurochemistry, 00, 1–18. https://doi.org/10.1111/jnc.15767
4. Figures

• National Center for Biotechnology Information. “PubChem Compound Summary for CID 10410568, Erinacine A” PubChem, National Center for Biotechnology Information. “PubChem Compound Summary for CID 132524618, Corallocin A” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Corallocin-A. Accessed 15 February 2023.

“PubChem Compound Summary for CID 76512895, N-de(phenylethyl)isohericerin” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/N-de_phenylethyl_isohericerin. Accessed 15 February 2023.

“PubChem Compound Summary for CID 10416073, Hericenone H” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Hericenone-H. Accessed 15 February 2023.

“PubChem Compound Summary for CID 10410568, Erinacine A” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Erinacine-A. Accessed 15 February 2023.

“PubChem Compound Summary for CID 15658905, Hericenone C” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Hericenone-C. Accessed 15 February 2023.

“PubChem Compound Summary for CID 15658906, Hericenone D” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Hericenone-D. Accessed 15 February 2023.

Header Image: By Lebrac – eigene arbeit von Lebrac, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=3528646