UCT Specialty Chemical Cited in Biomolecular Study

November 27th, 2017

In a recent paper published in ACS Biomaterials Science and Engineering by Darin Edwards et al., (DOI: 10.1021/acsbiomaterials.7b00596), UCT’s organosilane DETA (N-1 [3-(trimethoxysilyl) propyl]-diethylenetriamine, T2910KG) was used to form a monolayer on a microslide by the reaction of the cleaned surface with a 0.1% (v/v) mixture of the organosilane in freshly distilled toluene. These slides were used to study biological cultures involving N-Methyl-D-aspartic acid (NMDA) and α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) channel expression. The cultures were exposed to synaptic transmission antagonists against NMDA and AMPA channels which revealed significantly different receptor profiles of adult and embryonic networks in vitro.