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UCT SPE Column and Derivatizing Reagent Cited in Warfarin UKIAFT Presentation

UCT’s long chain C30 SPE was employed to analyze drugs in bottlefly larvae. The research aimed to determine whether varying concentrations of warfarin impacts the development of blue bottlefly larvae and to determine whether warfarin levels in this organism can be correlated to drug concentrations in tissues eaten by the larvae. This research was presented by Richard L. Harries et al., at  the UKIAFT annual meeting in Dublin.

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UCT Consumables Cited in Mephedrone Study

In a study published in Drug Testing and Analysis, J. Czerwinska et al., (doi: 10.1002/dta.2525), developed a liquid chromatography tandem mass spectrometry method using UCT’s Selectra® PFPP LC column for the simultaneous quantification of mephedrone and five of its phase I in human whole blood after extraction with UCT’s Xtrackt® solid phase extraction (SPE) columns. Mephedrone’s stability in whole blood has been previously investigated but this is the first-time stability of its metabolites has been assessed, indicating -20°C to be the recommended storage condition for all analytes.

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Clean Screen® DAU Cited in Opiate GC-MS/MS Article

In a recent paper published in Journal of Analytical Toxicology (doi: 10.1093/jat/bky077), authored by Mohammad Ali Al Saad et al., UCT’s Clean Screen®DAU was employed to extract opiates from whole blood. This method was validated for the simultaneous determination of codeine, morphine, 6-acetylmorphine (6-MAM), hydrocodone and hydromorphone in human blood samples

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UCT Sorbent Cited in TIAFT Fentanyl and 18 Novel Fentanyl Analogs Presentation

UCT’s famous Clean Screen® DAU was used to extract fentanyl and 18 additional compounds from whole blood samples. A fit-for-purpose method validation adapted from SWGTOX was performed by assessing the following criteria over five days: bias, precision, linear dynamic range, interferences and carryover.

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UCT 521 Enviro-Clean® 521 Sorbent Cited in Disinfection Study

In a recent paper authored by Wan-Ning Lee et al, published in Food Chemistry ((2018) 256 319-326) UCT’s Enviro-Clean® 521 solid phase extraction (SPE) cartridges were used to analyze 40 conventional and emerging DBPs in fresh cut produce wash water by modified EPA methods. The authors reported that good recoveries (60–130%) were achieved for most DBPs in deionized water and in lettuce, strawberry and cabbage wash water. The method detection limits are in the range of 0.06–0.58 μg/L for most DBPs and 10–24 ng/L for nitrosamines in produce wash water. 

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UCT Silane Cited in Plasmon Research Study

Ultrasensitive and selective detection and quantification of dopamine (DA) plays a key role in monitoring neurodegenerative diseases and the detection limit reported is typically in the lower nanomolar range. Pushing the detection limit to picomolar (pM) or lower for this particular target to cover the physiological levels (< 130 pM) is significant. In the following article, DA DNA aptamer (DAAPT) gold nanoparticle (AuNP) conjugate is utilized to enhance the surface plasmon resonance (SPR) signal, which enables to detect and quantify DA in the femtomolar (200 fM) to pM range.

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XtrackT® Cited in New Psychoactive Substances Article

In a recent paper published in Drug Testing and Analysis, UCT’s Xtract® solid phase extraction sorbent was used to extract a diverse range of new psychoactive substances (NPS) from samples of waste water. Temporal trends were found in wastewater with distinct tendencies for synthetic cathinones visible over the period studied.

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UCT Flagship Sorbent Clean Screen® DAU cited in Cardiac Study

In a recent study by Guillermo Alberto Keller et al., published in Journal of Opioid Management , UCT’s Clean Screen® DAU was used to extract Propoxyphene (DPX)  and norpropoxyphene (NPX) from human plasma and analyzed by GC-MS. Plasma samples (500 µl) were treated with a strong alkali hydroxide to form NPX amide and extracted using CSDAU203. The recovery of the procedure was higher than 81%.  

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UCT’s DETA cited in Stem Cell Research Study

In a recent paper authored by Navaneetha Santhanam et al, published in Biomaterials ((2018) 166 64-78), UCT’s specialty chemical 3-trimethoxysilyl propyl diethylenetriamine (DETA), an amine-terminated alkylsilane, was employed to promote cell adhesion. This study was designed to develop and evaluate a prototype of a drug-screening platform for neuromuscular junctions at different modes of operation: presynaptic and/or postsynaptic

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UCT Flagship Sorbent Cited in Khat Analysis Study

In a recent study authored by Ibraheem M. Attafi et al., published in the Arab Journal of Forensic Sciences & Forensic Medicine ((2018) 7(1) 922-930)), a postmortem case report aimed to identify and determine the concentration of cathine and cathinone in different body organs and green chewed plants found in the mouth of the deceased. Extraction of the khat compounds was performed using UCT’s Clean Screen® DAU in conjunction with LC-MS/MS quantitative analysis to confirm that samples were positive for cathinone and cathine.

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DAU Sorbent cited in Equine Toxicology Study

In a recent study published in Drug Testing and Analysis (DOI: 10.1002/dta.2378), authored by Heather K. Knych et al, UCT’s Clean Screen® DAU was employed to extract grapiprant following oral administration to exercised thoroughbred horses. Grapiprant is a newly approved non‐ cyclooxygenase inhibiting non‐steroidal anti‐inflammatory drug that has demonstrated efficacy and safety in other species. As long‐term use of these drugs can adversely impact the health of the horse, anti‐inflammatories with a more favorable safety profile are warranted.

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UCT XtrackT® Solid Phase Extraction Sorbent Cited in Environmental Analysis Article

UCT’s XtrackT® solid phase extraction sorbent (XRDAH506) was employed in a validated method to isolate several illicit drugs from urban waste water samples in South Australia. The occurrence of five drugs of abuse in raw influent and treated effluent wastewater was investigated over a period of 1 year in Adelaide. Results showed that all the targeted drugs were on average incompletely removed by wastewater treatment, with removal performance highest for morphine (94%) and lowest for MDMA (58%). 

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UCT QuEChERS Cited in Agro-Industry Article

In a recent paper published in Food Chemistry by Claudio Alister et al., (oi: https://doi.org/10.1016/ j.foodchem.2018.06.090), A UCT’s QuEChERS blend containing 4 g magnesium sulfate (MgSO4), 0.5 g of disodium citrate (C6H6Na2O7), 0.5 g of trisodium citrate (Na3C6H5O7) and 1 g of sodium chloride (NaCl) was employed in the primary extraction of  pesticides from prunes. In the secondary clean up stage, 1.5 g MgSO4 and 0.25 g of PSA (UCT Selectra®) were used.

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UCT Clean Up® Solid Phase Extraction Sorbent cited in Mycotoxin Study

In a recent paper authored by Lia D. Murty et al., published in Journal of Agricultural and Food Chemistry (DOI: 10.1021/acs.jafc.8b00963), UCT’s Clean Up® solid phase extraction silica was employed in the study of co-exposure of the mycotoxins Lolitrem B and Ergovaline in steers fed perennial ryegrass (Lolium perenne) straw. Past research showed a strong linear correlation between levels of the two mycotoxins in ryegrass.

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UCT Specialty Chemical cited in Mechanobiology Study

In a recent article published in Lab on a Chip, authors Donghee Lee et al., (DOI: 10.1039/C8LC00320C), used UCT’s specialty chemical (Tridecafluoro-1, 1, 2, 2-Tetrahydrooctyl)-1- Trichlorosilane (T2492-KG) in a mold-making process. This involved the production of a microfluidic cell compression device that improved a microfluidic device proposed previously by equipping it with an array of cell compression units. The device contained a 5×5 array of alginate-chondrocyte constructs. This microfluidic cell was employed to investigate human cartilage cells. T2492-KG played an integral part of this procedure.

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UCT Derivatizing Reagent cited in Forensic Anthropology Study

In a recent study, authored by Susan Luong et al., (Forensic Science International ((2018), 285 93-104)) UCT’s derivatizing reagent O-Bis(trimethylsilytrifluoroacetamide) containing 1% trimethylchlorosilane (BSTFA (1% TMCS)) was employed to assist with the gas chromatographic-mass spectrometric (GC-MS) analysis of a cadaveric break down product. In this research, a human cadaver was placed on the surface of a designated plot at the Australian Facility for Taphonomic Experimental Research (AFTER), the only human decomposition facility in Australia. The natural process of decomposition was allowed to progress over fourteen days during the summer.

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UCT Clean Screen® DAU Cited in 3-Methylfentanyl Article

3-Methylfentanyl (3-MF) has reappeared in the United States illicit drug market for the first documented time since 1988. In a paper authored by Melissa F. Fogarty et al., published in Drug Testing and Analysis (doi: 10.1002/dta.2414) an analytical method was developed and validated using UCT’s flagship sorbent Clean Screen® DAU (130 mg/ 3 mL). Liquid chromatography time-of-flight mass spectrometry was the instrument of choice for the analysis of (±)- cis-3-MF and (±)-trans-3-MF in blood specimens. The linear dynamic range of this method was 0.1-10 ng/mL.

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UCT Specialty Chemicals Cited in Cancer Study Article

In a recent paper authored by Xiaoying Wang published in Talanta ((2018) 187 179-187), UCT’s specialty chemicals Tetraethylorthosilicate (TEOS) and trimethoxysilylpropy-diethylenetriamine (DETA) were employed in the process to produce an electrochemiluminescence (ECL) biosensor for detection of CdkN2A/p16 anti-oncogene based on functional electrospun nanofibers and core-shell luminescent composite nanoparticles.

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UCT Clean Screen® DAU Cited in Novel Fentalogs Article

Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. They both have been reported by the Drug Enforcement Administration in their third quarter report of 2017 to have been chemically identified seven and five times, respectively. In a recent paper authored by Melissa F. Fogarty et al., published in Journal of Analytical Toxicology (doi: 10.1093/jat/bky035), an analytical method was developed and validated to extract fentalogs from whole blood samples using UCT’s Clean Screen ® DAU. The method used LC-MS/MS for the quantitation of fentanyl, norfentanyl and 17 fentanyl analogs. 

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UCT QuEChERS Used for Analysis of Herbicide in Infant Formula

Haloxyfop is a selective herbicide that is used to protect crops such as potatoes and carrots against persistent grasses. In a recent paper authored by Urairat Koesukwiwat et al., (Analytical and Bioanalytical Chemistry https://doi.org/10.1007/s0021), the authors developed and validated a simple method for total haloxyfop analysis in infant formula and related ingredient matrices using UCT’s QuEChERS and liquid chromatography-tandem mass spectrometry (LC-MS/MS). 

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UCT QuEChERS Extraction Salts Cited In PFASs Study

Per- and polyfluoroalkyl substances (PFASs) are widely used in the manufacturing of various industrial and consumer products including nonstick food packaging, stain repellents and aqueous film-forming foams. In a recent paper published in Chemosphere ( (2018) 199 168-173) by Adcharee Karnjanapiboonwong et al., UCT’s QuEChERS extraction salts (4,000 mg MgSO4/1,000 mg NaCl) were employed to extract PFAS and other carboxylic acid compounds from earthworms. This was the first study on earthworms in PFAS-spiked soil at background concentrations. It was found that PFASs can be detected in earthworms even in the 0.1 mg kg1 soil treatment after 21-day exposure.

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UCT’s Clean Screen® DAU cited in NPS article

Mitragynine is a novel psychoactive substance (NPS) that has emerged as a designer opioid. Also known as kratom , it possesses both stimulant-like and sedative effects due to dual-binding of α-adrenergic and μ-opioid receptors. This herbal remedy is readily available online and can cause adverse effects including tachycardia, agitation, tremors, hallucination and death. In a recent article published in Journal of Analytical Toxicology by Trista H. Wright, UCT’s flagship sorbent, Clean Screen® DAU, was employed to extract the drug from whole blood. The author reports that a suspect in a driving under the influence case admitted to using Mitragynine to a drug recognition expert (DRE) officer.

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UCT Silane Cited in Clinical Microbiology Article

In a recent paper authored by Wanyuan Ao et al., published in Journal of Clinical Microbiology (doi.org/10 .1128/JCM.00982-17), UCT’s polymer amine-functional T-structure polydimethylsiloxane ([TSPS] was used in the manufacturing process to coat crystalline silicon wafers in which curing took place at 150°C for 24 hours. The crystalline silicon chip is integral to the analytical process.

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UCT Silane Cited in Organ-On-Chip Article

Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micro-patterned substrates, which limits turnover and flexibility of prototyping. In a recent paper authored by Janna C. Nawroth et al., published in Biofabrication ( Biofabrication ((2018) 10 025004), UCT’s silane chemicals were used for soft lithography fabrication of stamps for micro-molding hydrogels. The authors developed a rapid and automated method for large scale on-demand micro-patterning of gelatin hydrogels for organ-on-chip applications using a novel biocompatible laser-etching approach.

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UCT Clean Screen® EtG SPE Sorbent cited in Alcohol/Drugs Licensing Article

Elena Lendoiro et al., published in Forensic Science International (/doi.org/10.1016/j.forsciint.2018.03.023) on the use of UCT’s Clean Screen® EtG solid phase extraction sorbent to determine the ethyl glucuronide (EtG) content of drivers suspected of alcohol/drugs driving cases under voluntary conditions. A validated analytical method for EtG was established which had a limit of quantification (LOQ) of 5 pg/mg of hair. It was found that 22 hair samples were positive for EtG where concentrations (20.7-1254.1pg/mg) were higher than the Society of Hair Testing (SoHT) cut-off for chronic alcohol consumption (≥30 pg EtG per mg of hair) in 21 cases.

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UCT PSA Sorbent Cited in Sulfonamides and Trimethoprim Fish Analysis Paper

Brazil is one of the largest veterinary markets in the world, and aquaculture, in particular fish farming, is the fastest growing sector of animal food production in the country. In fish farming, antimicrobials, including sulfonamides, are used for the treatment of bacterial diseases. Sulfonamides belong to an important group of synthetic antimicrobial agents that have been used in human and veterinary medicine for over 60 years. Recently, these drugs have been extensively employed in animals intended to produce food for human consumption.

In a recent paper authored by Katia Nunes et al., published in Journal of Analytical Methods in Chemistry (doi.org/10.1155/2018/4506754), a multiresidue method for detecting and quantifying sulfonamides (sulfapyridine, sulfamerazine, sulfathiazole, sulfamethazine, sulfadimethoxine, sulfamethoxazole, and sulfamethoxypyridazine) and trimethoprim in tilapia fillet (Oreochromis niloticus) was developed and validated using UCT's QuEChERS clean-up products in conjunction with liquid chromatography- mass spectrometry (LC-MS/MS). 

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Congratulations to Mariem Al Bouwalda - Recipient of the 2018 UCT Sponsored "Best Overall Chemistry Performance" from the Dublin Institute of Technology!

UCT would like to extend our warmest congratulations to Mariem Al Bouwalda for winning the 2018 UCT sponsored "Best Overall Chemistry Performance" in the specialized field of Nanotechnology. Mariem is a student at the Dublin Institute of Technology's School of Chemistry & Pharmaceutical Sciences. She was presented with the prestigious award celebrating student research and ingenuity on February 22nd, 2018. 

Once again, on behalf of everyone at UCT, Congratulations Mariem on your outstanding work and we wish you all the luck in your future scientific endeavors!

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UCT Enviro-Clean ® 521 Cartridges cited in Emerging Disinfection Bi-Products Article

In produce processing, water used to wash both fresh and fresh-cut produce is commonly treated with sanitizers for the purpose of controlling pathogens and minimizing microbial cross-contamination. Chlorine-based sanitizers are most commonly used for produce processing in the food industry (FAO/WHO, 2008). While chlorine’s efficacy in controlling pathogens is well recognized, one of the main concerns is the reactivity of chlorine with organic and inorganic substances to generate harmful disinfection bi-products (DBPs) and emerging DBPs of concern including haloacetonitriles, halonitromethanes, haloacetamides, and nitrosamines (NISAMs). Monitoring these DBPs is necessary to protect food safety but comprehensive analytical methods have been lacking. 

In a recent paper authored by Wan-Ning Lee et al., published in Food Chemistry (https://doi.org/10.1016/j.foodchem.2018.02.134), UCT’s Enviro-Clean® 521 sorbent (200 mg/ 6 mL) was employed to analyze DBPs and NISAMs in food wash water. 

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UCT Clean Screen® DAU Cited in Umbilical Cord Drug Testing Article

Analysis of umbilical cord samples offers forensic toxicologists a method for evaluating maternal drug intake patterns. These matrices may be an uncommon sample for many laboratories, but for those that are tasked with the challenge, solid phase extraction offers the most efficient methodology for the analysis of said compounds.

In recent paper authored by Amy Alexander et al., in Journal of Analytical Toxicology (doi: 10.1093/jat/bky009), UCT’s flagship sorbent Clean Screen®DAU (CSDAU020) was employed to analyze samples of umbilical cord taken from two monozygotic twins. It was found that the umbilical cord from newborn #1 was positive for hydromorphone only (1.06 ng/g), and the umbilical cord from newborn #2 was positive for hydromorphone (0.81 ng/g) and benzoylecgonine (5.41 ng/g).

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UCT Flagship Sorbent Clean Screen® DAU Cited in Oral Cocaine Study

For many forensic toxicologists, studying the biological pathways of illicit drugs is important if offering interpretation to the submitting agents. One of the most common drugs seen by forensic toxicologists on a routine basis is cocaine. The pharmacokinetic profile of oral cocaine has not been fully characterized and prospective data on oral bioavailability is limited. In a recent paper published in Journal of Analytical Toxicology (doi: 10.1093/jat/bky007) by Marion A.Coe, set al., a within-subject study was performed to characterize the bioavailability and pharmacokinetics of oral cocaine. This study was performed using UCT’s most famous solid phase extraction (SPE) sorbent Clean Screen DAU®(ZSDAU020) to extract the compound and metabolites.

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UCT Flagship Sorbent Clean Screen DAU cited in SOFT-TIAFT U-4700 Presentation

Several deaths in the US and Europe have been attributed to U-47700 both alone, and in combination with other drugs. In a presentation given at the recent SOFT-TIAFT conference in Boca Raton by M.L. Zaney et al., postmortem cases from a regional medical examiners laboratory in Florida, USA were presented in which U-47700 was detected either in blood or drug paraphernalia. In the study, whole blood specimens were extracted using UCT’s flagship Clean Screen® DAU solid phase extraction (SPE) columns. 

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Join UCT at the Medical Cannabis Educational Summit March 5th, 2018!

Harrisburg Area Community College (HACC) is hosting its Spring 2018 Medical Cannabis Educational Summit. UCT, in conjunction with Shimadzu Scientific Instruments, will be leading a symposium for those who work in cannabis testing laboratories or are looking to start one.  Talks will be given on sample preparation, chromatography, quantitation of cannabinoids and the regulation of cannabis.  The event will provide scientific insight into the ever expanding cannabis market.  Click below to register and learn more about the event: https://www.eventbrite.com/e/medical-cannabis-educational-summit-tickets-39125969829?aff=HACCWebsite

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UCT Flagship Sorbent Clean Screen® DAU Cited in SOFT-TIAFT Meeting Presentation

In a presentation at the recent joint annual meeting of Society of Forensic Toxicologists (SOFT) and The International Association of Forensic Toxicologists (TIAFT) held in Boca Raton, Florida, USA, Jamie Foss et al., employed UCT’s famous flagship sorbent, Clean Screen® DAU (CSDAU 130 mg/3 mL), in a study concerning the determination of matrix suppression in blood/urine samples by liquid chromatography-tandem mass spectrometry. The study involved the solid phase extraction (SPE) of benzoylecgonine, carboxy-THC, Fentanyl, 6-monoacetyl morphine, and hydrocodone and the related matrix effects.

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UCT Flagship Sorbent Cited in Synthetic Fentanyl Analysis Article

In a recent paper authored by Kraig E. Strayer et al., published in ACS Omega ((2018) 3 514-23), UCT’s famous flagship sorbent Clean Screen ® DAU was employed to extract fentanyl analogs from whole blood. The authors describe the development and validation of a solid phase extraction (SPE) process combined with liquid chromatography tandem mass spectrometry-based method for the multiplex detection of  24 illicitly manufactured fentanyl analogues and metabolites in whole blood at concentrations as low as 0.1−0.5 ng per mL using the UCT sorbent. 

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UCT Specialty Chemical cited in Monolithic Chromatography Study

Monolithic materials are versatile adsorbents widely employed in separation science, sample preparation and as supports for flow through applications (e.g. heterogeneous catalysis, ion-exchange, solid-phase extraction, etc). Interest around their preparation and applications has been steadily on the rise. In a recent paper published in Journal of Chromatography A ((2017) 498 46-55) by Patrizia Simonea et al., UCT’s specialty chemical N-trimethoxysilylpropyl)-polyethylenimine was employed in the production of capillary methacrylate-based monoliths. This process was executed by grafting from/to ƴ -ray polymerization on a tentacle-type reactive surface for the liquid chromatographic separations of small molecules and intact proteins.

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Congrats to Sara Demspey, Timothy Lau, and Raquel Leblanc - Winners of the 2017 SOFT Excellence in SPE Awards!

UCT would like to extend our warmest congratulations to Sara Demspey, Timothy Lau, and Raquel Leblanc - Winners of the 2017 SOFT Excellence in SPE Awards. This award appropriately reflects the recent outstanding contributions they made to the field of Solid Phase Extraction in Forensic Science. 

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UCT Derivatizing Reagents Cited in ATS Study

Amphetamines Type Substances (ATS), which include amphetamine (AMP), methamphetamine (MA), 4-methylamphetamine (4-MA), 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), cathinone (CAT), and ephedrine (EPH), are widely acknowledged as common identified drugs of abuse.  Alternative, new-age synthetic cathinones such as methcathinone (MC) and mephedrone (MEP) are frequently observed in forensic toxicology cases but were originally marketed as “bath salts”. In a new paper authored by Khaled M Mohamed and Abdulsallam Bakdash published in Analytical Chemistry Insights ((2017) 12 1–16), UCT’s high-puritiy fluoroacyl derivatization reagents were employed in the analysis of ATS extracted from oral fluid (OF) samples using gas chromatography-mass spectrometry (GC-MS). 

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UCT XtrackT® Sorbent Cited in Drugs in Wastewater Article

Environmental analysts are often tasked with the evaluation of illicit and prescription drugs in wastewater samples in an attempt to better understand the epidemiology of a populated area. Due to the challenging consistency of this matrix, clean-up is often vital in order to achieve accurate detection. In a recent paper authored by Richard Bade et al., published in Analytical and Bioanalytical Chemistry (doi.org/10.1007/s0021), UCT’s Xtrackt®, large-particle, solid-phase extraction (SPE) cartridges (XRDAH506) were utilized for the detection of licit and illicit drugs in wastewater samples in Southern Australia.

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UCT's Clean Screen® Xcel /FASt Sorbents Cited in Phenothiazine Study

For many forensic toxicologists working with active drugs, the parent substrates may not be present in biological matrices, only the metabolites. From these metabolites, the parent drug may be assessed. This is typically performed by characterization of both the parent and metabolites. In a recent paper authored by Courtney Campbell et al., in Journal of Analytical Toxicology (doi: 10.1093/jat/bkx067), a validated method for the characterization of degradation products formed from selected phenothiazine drugs was employed utilizing solid-phase extraction (SPE) and UCT’s XCEL1 (130 mg in 48 well plate format). 

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UCT’s CUNAX2 Solid Phase Sorbent Cited in Surfactant Article

Many contaminants are now entering the composition of industrial and domestic products (personal care products, cosmetics, detergents, etc.). Following a massive and varied use of these products, significant amounts of pollutants can be found at different levels of the water cycle, particularly in urban areas. Healthcare facility discharges, by their nature, are often considered as non-domestic effluent, which can provide significant pollution comparatively to other domestic sources. In a recent paper authored by Alexandre Bergé et al., published in Environmental Science and Pollution Research (doi.org/10.1007/s11356-017-0470-8), UCT’s mixed-mode anion exchange solid phase extraction (SPE) cartridges, CUNAX2 (200 mg/ 3 mL), were employed for the extraction/preconcentration of surfactants in waste water samples.

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UCT Flagship Sorbent Clean Screen DAU cited in Piperazines Stability Study

Of all the drugs plaguing analytical forensic toxicologists, the newer psychoactive substances (NPS) are the most challenging. One of the older NPS’s is the Synthetic Piperazines (SP) class. While circumventing legislative controls, SP’s are encountered as “legal” alternatives to ecstasy. Forensic toxicologists often meet unforeseeable challenges that may delay quantitative analysis of these compounds in biological fluids. Enzymatic reactions, matrix interferences and limited knowledge of analyte stability further complicate interpretation of calculated concentrations in the wide range of matrices submitted to the laboratory for analysis. In a recent paper published in Journal of Analytical Toxicology by Timothy Lau et al., (doi: 10.1093/jat/bkx090) the stability of SP's in human blood under various storage conditions over time was investigated using UCT’s famous flagship sorbent Clean Screen® DAU for the extraction process.

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UCT Specialty Chemical Cited in Biomolecular Study

In a recent paper published in ACS Biomaterials Science and Engineering by Darin Edwards et al., (DOI: 10.1021/acsbiomaterials.7b00596), UCT’s organosilane DETA (N-1 [3-(trimethoxysilyl) propyl]-diethylenetriamine, T2910KG) was used to form a monolayer on a microslide by the reaction of the cleaned surface with a 0.1% (v/v) mixture of the organosilane in freshly distilled toluene. These slides were used to study biological cultures involving N-Methyl-D-aspartic acid (NMDA) and α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) channel expression. The cultures were exposed to synaptic transmission antagonists against NMDA and AMPA channels which revealed significantly different receptor profiles of adult and embryonic networks in vitro.

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UCT Silane Cited in Biomolecular Engineering Paper

In a paper authored by E. L. Jackson-Holmes et al., in Lab on a Chip ((2017), 17, 3634), UCT’s silane, tridecafluoro-1,1,2,2- tetrahydrooctyl-1-trichlorosilane, was employed in an integral role in a vapour form to produce a polydimethylsilane (PDMS) master in a procedure in which a microfluidic platform was developed for culture, longitudinal monitoring, and phenotypic analysis of individual stem cell aggregates. This novel platform uses a hydrodynamic loading principle to capture pre-formed stem cell aggregates in independent traps. 

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Explore UCT's Ultra Flash® and Metal Scavenging Lines!

Ultra Flash® I: Standard Ultra-Pure Silica Line

Ultra Flash®II: Spherical High Pressure Silica Line 

Ultra Flash® III: iLOK® Pre-packed Standard Ultra-Pure Silica Line 

 

• 100% guaranteed leak-free 
• Clean, pre-packed, pharmaceutical-grade polypropylene cartridges 
• Made with ultra-pure normal phase silica gel 
• Easy purification with disposable columns provided in an extensive range...
• 100% compatibility with other instruments: 
   ◘ Teledyne Isco (CombiFlash® : Rf, Companion®, RETRIEVE®, OptiX®
   ◘ Biotage (IsoleraTM, SP, Flash, FlashMaster II) 
   ◘ Analogix (Varian) (IntelliFlash 310 and 280, SimpliFlash, F12/40) 
   ◘ Interchim (PuriFlashTM 430evo) 
   ◘ Grace (Reveleris® System) 
   ◘ Armen (Spot Flash System) 
   ◘ Yamazen (Smart Flash EPCLC W-Prep 2XY) 
   ◘ BUCHI (Sepacore®)

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Join UCT for an upcoming Separation Science Forensics & Toxicology e-Seminar November 28 & 30th, 2017!

Separation Science has developed its fourth online eSeminar focusing on advances in forensics and toxicology. Taking place in two sessions, one each on 28 and 30 November 2017, this two-day online educational event will provide forensic scientists, toxicologists and those who work in laboratories within the forensic and toxicology industries with updates and guidance on the latest methods, protocols, processes and applications of chromatography, mass spectrometry and related techniques with key experts providing practical insights into their respective fields.

Our very own Forensic Technical Specialist, Tina Fanning, will be presenting in conjunction with an extensive panel of additional key experts in the field. The e-Seminar will comprise 7 presentations over 2 sessions featuring UCT's platform topic, "A Modified QuEChERS Approach for the Extraction of Common Prescription and Illicit Drugs from Liver Prior to LC/MS-MS Analysis." Click below to register for this exciting and informative event: 

http://webinar.sepscience.com/advances-in-forensics-and-toxicology-eseminar-form

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UCT Clean Screen FASt® cited in Forensic Toxicology Study

Of the challenges facing forensic toxicologists working in the post mortem field, the analysis of decomposed or skeletal remains for the presence and concentrations of drug compounds may be the most difficult. The use of bone as a matrix for toxicological analysis has been investigated extensively since 2000. These studies, involving both human and animal remains, have shown a wide variability in detected drug and metabolite levels across different bone types. Interpretation of toxicological measurements in bone is also complicated by the inability to properly determine analyte recovery from bone tissue. In a recent study published in Drug Testing and Analysis by H. M. Cornthwaite et al., (doi: 10.1002/dta.2327), UCT’s world famous Clean Screen FASt® solid phase extraction sorbent in 96 well plate format (100 mg bed mass) was employed to extract tramadol (TRAM), dextromethorphan (DXM) and their respective metabolites from skeletal remains. 

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UCT MSTFA Derivatizing Reagent Cited in Archaeological Study

The determination of original source of use-related residues on prehistoric stone tools is especially challenging, due to issues related to preservation, contamination and multiple source residue the contributions. To increase confidence in this process, an analytical workflow was developed by Susan Luoing et al., published in Analytical Methods (2017, 9, 4349) which included a sampling strategy that retains spatial information of the recovered residues and enables monitoring of environmental contamination; and a sensitive and selective gas chromatography-tandem mass spectrometry (GC-MS/ MS) procedure to quantify non-volatile low molecular weight lipids on stone artefacts. Representative aliquots were spiked with internal standards.  After extraction of the lipids and evaporation of the extracts, the samples were derivatized with UCT’s MSTFA (N-Methyl-N-trimethylsilyltrifluoroacetamide) containing 1%TCMS (1% trimethylchlorosilane) silylation reagent.  

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UCT QuEChERS Kits Cited in Cranberry Perfluoroalkyl Substances Study

Perfluoroalkyl and polyfluoroalkyl substances (PFASs), in particular perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS), have been widely studied due to their persistence, distribution, toxicity and bio-accumulation in humans and the environment. These compounds can enter the environment through landfills (products containing stain repellents, food packaging), wastewater treatment plants (industry waste) and from the use of firefighting foams (aqueous film-forming foams [AFFFs]). In a recent study by Susan Genualdi et al., (FOOD ADDITIVES & CONTAMINANTS: PART A, 2017 https://doi.org/10.1080/19440049.2017.1361046 ), UCT’s QuEChERS kits (AOAC 2007.1, 6 g MgSO₄ with 1.5 g NaCl) and dispersive SPE (dSPE) sorbent (0.9 g MgSO₄, 0.3 g primary secondary amine [PSA], 0.15 g graphitized carbon black [GCB]) and were used for the extraction of PFAS in cranberries. 

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UCT Silane Cited in Cellular Research Article

In a recent article published in Lab on Chip by E.L. Jackson-Holmes et al., (DOI: 10.1039/C7LC00763A), tridecafluoro-1,1,2,2-tetrahydrooctyl-1-trichlorosilane from UCT was integral in the production of a mold to perform their intended research. In the procedure, a master mold was fabricated by standard UV photolithography with the negative photoresist to create three layers of respective heights 200 μm, 100 μm, and 200 μm. In making the polydimethylsilane (PDMS) molding, the master was treated with the UCT silane vapor to allow release of the PDMS. These three-dimensional pluripotent stem cell (PSC) cultures have the ability to undergo differentiation, self-organization, and morphogenesis to yield complex, in vitro tissue models that recapitulate key elements of native tissues.  For more information on UCT specialty chemicals visit https://specialties.unitedchem.com/

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UCT Silane (TSPS) cited in Microbiology Article

Numerous polymerase-chain-reaction (PCR) and isothermal amplification methods employed currently in molecular diagnostic assays have been developed, significantly improving assay sensitivity and specificity as well as shortening overall time. In spite of this objective, nucleic acid target amplification continues to present challenges for dealing with “false-positive” results due to environmental or reagent contaminants introduced during the testing process. This has been addressed in a recent article authored by Wanyuan Ao et al., published in PLoS ONE 12(2): e0171915 in which UCT silane amine-functional T-structure polydimethylsiloxane (TSPS) was described in the production of crystalline silicon wafers. In this paper, the authors describe a strategy that can distinguish between staphylococcus species truly present in a clinical sample from contaminating staphylococcus species introduced during the testing process.

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UCT Flagship Sorbent Clean Screen® DAU cited in Carfentanil Study

In a new paper authored by Szabolcs Sofalvi et al., published in Journal of Analytical Toxicology ((2017) 41 473–483), a validated method for the extraction of fentanyl, norfentanyl, acetyl fentanyl, carfentanil, 2-furanyl fentanyl and 3-methylfentanyl was reviewed using Clean Screen®  DAU and LC-MS/MS to identify these novel compounds along with their corresponding concentrations.

 

 

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UCT Flagship Sorbent Clean Screen® DAU cited in Novel Psychoactive Substance (NPS) Study

The analysis of hair provides forensic toxicologists with several significant benefits in casework. Not only is it utilized when more conventional matrices such as blood and urine are not available, but also it provides an approximate timeline of drug use. Hair analysis is particularly useful in cases of child custody, workplace drug testing or in drug facilitated sexual assault cases. In a new paper authored by Lorna A Nesbit et al., published in Journal of Analytical Toxicology (doi: 10.1093/jat/bkx053) a group of NPS compounds (25B-, 25C- and 4-iodo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine) and 25I-NBOMe, using 4-bromo-2,5-dimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine (25B-NBOMe)-D3, were analyzed using UCT’s flagship SPE sorbent Clean Screen® DAU (CSDAU133).  

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UCT Flagship Sorbent Clean Screen® Cited in Synthetic Cathinones Study

In recent years, the abuse of newer psychoactive substances (NPS) such as synthetic cathinones or ‘bath salts’ has become a major public health concern. These compounds were initially sold legally and labeled “not for human consumption.” Three popular drugs of this type are methylone, mephedrone, and 3, 4-methylenedioxypyrovalerone (MDPV). Unfortunately, there is currently no information available on the teratogenicity of these compounds, or of the extent to which they cross the placenta. In a recent paper authored by Lauren G. Strange et al., published in the journal Neurotoxicology and Teratology ((2017) 63 9–13) this issue was  addressed by employing UCT’s flagship sorbent Clean Screen® DAU followed by analysis utilizing HILIC LC-MS/MS. The purpose of this study was to examine the pharmacokinetic profile of the ‘bath salts’ in a pregnancy model using an animal model.

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UCT's CUQAX SPE sorbent cited in Perfluorinated Organic Substances (PFOS) article

In a recent paper authored by Jana H.Johansson et al, published in the journal Emerging Contaminants ((2017) 3 46-53)), UCT’s world famous Clean Up® QAX sorbent was employed in a study involving the analysis of PFOS, especially water-to-air transfer of branched and linear perfluorooctanoic acids (PFOA).UCT is known around the world for the production of the finest sorbents for environmental type extractions and PFOS are now gaining recognition as compounds of environmental interest. In this study, the volatilization of perfluorooctanoic acid (PFOA) was measured experimentally at a range of pH values using a validated laboratory method published by the authors. 

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UCT Flagship Sorbent Clean Screen® DAU Cited in Opioids Study

In a recent paper authored by Nicolás Fernández et al., published in Rapid Communications in Mass Spectrometry (DOI10.1002/rcm.7933), the researchers describe a new method in which UCT’s flagship sorbent, Clean Screen® DAU (CSDAU303), was used for the simultaneous quantification of Meperidine, its main metabolite Normeperidine,Tramadol, Propoxyphene, and its main metabolite Norpropoxyphene in plasma samples. 

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UCT Clean Screen® THC Column Cited in Post Mortem Study

Marijuana, known for its euphoric and relaxing properties, continues to be the most commonly abused illicit drug globally. While the substance has numerous desirable affects like those noted above, long-term use has been shown to result in impaired memory, cognitive skills and psychomotor function through the psychoactive properties of tetrahydrocannabinol (THC) and its hydroxylated metabolite (THC-OH). UCT has been at the forefront of the analysis and quantification of THC and THC-OH in biological fluids through the use of the Clean Screen® THC sorbent and extraction column.   

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Congratulations to Sara McGrath at the FDA Center for Food Safety and Applied Nutrition for winning the 2017 NACRW Excellence in Sample Prep Award!

UCT would like to extend our warmest congratulations to Sara McGrath at FDA Center for Food Safety and Applied Nutrition for winning the 2017  NACRW Excellence in Sample Prep Award sponsored by UCT. The winning poster presentation was entitled, "Strategies for Extraction and Purification of Tetrodotoxin and Saxitoxin from Fish Filets with LC-MRM/MS Analysis."

Once again, on behalf of everyone at UCT, Congratulations Sara on your outstanding research!

 
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UCT’s Clean Screen® Xcel 1 SPE 96 Well Plates Cited in Animal Study

The correlation of drugs in decomposed human remains and animals is very useful for forensic toxicologists working with complex matrices that go beyond post mortem samples.  In a recent paper published in Journal of Analytical Toxicology, Lucas M. Morrison et al.,(doi: 10.1093/jat/bkx040)  employed UCT’s famous Xcel I SPE sorbent to extract Dextromethorphan (DXM) and its primary metabolite (DXT) from the remains of rats. They analyzed DXM and DXT in skeletal remains of rats following acute (ACU, 75 mg/kg, IP, n = 10) or three repeated (REP, 25 mg/kg, IP, n = 10, 40-minute intervals) doses of DXM. 

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UCT Dispersive SPE Sorbent Cited in Anticoagulant Rodenticides Article

In a new paper by Lori Smith et al, published in the Journal of Food and Agricultural Chemistry (DOI: 10.1021/acs.jafc.7b02280), a wide and diverse range of anticoagulant rodenticides (ARs) were analyzed in rodent liver samples using UCT's dispersive SPE (d-SPE) tubes for sample clean-up. ARs are used to control rodent populations, acting as vitamin K antagonists by inhibiting vitamin K epoxide reductase. Consequently, formation of prothrombin and related blood-clotting factors (VII, IX and X) are blocked, causing massive hemorrhage and mortality. 

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UCT Flagship Clean Screen® DAU cited in NPS Article

UCT is well-recognized for its flagship solid phase extraction (SPE) sorbent Clean Screen® DAU. This acclaimed sorbent is employed by many forensic toxicology laboratories for the extraction of drugs and metabolites from biological matrices, including the increasingly encountered novel psychoactive substances (NPS). In a new paper authored by C.Mitchell-Mata in Journal of Analytical Toxicology (doi: 10.1093/jat/bkx048), CSDAU206 was used to extract 3- and 4-methoxyphencyclidine (3-MeO-PCP, 4-MeO-PCP) in forensic cases.

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UCT QuEChERS Kits Cited in Neonicotinoid Identification in Honey

UCT, the first company to commercialize the QuEChERS technique, still maintains its support for facilities around the world analyzing food samples for the detection of herbicides, pesticides, and insecticides. The most widely used class of the insecticides in last twenty years are neonicotinoids, which act as receptor agonists of nicotinic acetylcholine. In a paper published in Journal on Processing and Energy in Agriculture by P. Jovanov et al., (2017) 21, 53-55)), UCT’s famous QuEChERS  buffered sample extraction kit , ECQUEU750CT,  and general dispersive cleanup kit,  ECMPS15CT, were used in the extraction of honey samples taken from the Province of Vojvodina, Poland, for the presence of neonicotinoids. 

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UCT Clean Screen ®THC cited in Drugs and Driving Study from Orange County, California

Driving under the influence of drugs (DUID) has become a growing issue nationwide and likewise in Orange County (OC), California. In research published in Journal of Forensic Sciences by K. Declues et al., UCT’s famous Clean Screen® THC SPE cartridges were used to extract cannabinoids from samples of whole blood taken from apprehended drivers in OC over a two-year period. In this study (Part II of a two stage study), a comparison was conducted of examined objective signs, eye examinations and physiological indicators with their relationship to the presence of identified concentrations of THC. 

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UCT Flagship Sorbent Clean Screen® DAU cited in Beta Blockers/Beta Agonists Paper

UCT's flagship solid phase extraction (SPE) sorbent, Clean Screen® DAU, has been employed by countless forensic toxicology laboratories for the extraction of various drugs and metabolites from biological samples. In a recent paper published in Journal of Chromatographic Science (doi: 10.1093/chromsci/bmx045) by A.A. Salem et al, this acclaimed sorbent (130 mg in 3 mL format) was effectively utilized to isolate β-blockers and β2-agonists from human plasma and urine.

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UCT Xtrackt® SPE Columns Cited in Horse Steroid Analysis Article

In the field of animal sports toxicology, UCT is recognized around the world as the premier manufacturer of the finest sorbents for the extraction of steroids and other doping agents in equine urine. In a recent paper published in Journal of Pharmaceutical and Biomedical Analysis by H.D.Shin et al., (doi= 10.1016/j.jpba.2017.06.036) a high throughput method for simultaneous screening of anabolic steroids and their metabolites (4-esterendione, trenbolone, boldenone, oxandrolone, nandrolone, methandrostenolone, testosterone, 1-androstendione, ethisterone, normethandrolone, methyltestosterone, 16β-Hydroxystanozolol, epitestosterone, bolasterone, norethandrolone, danazol, stanozolol and androstadienone) in equine urine was developed using UCT’s large particle Xtrackt® SPE sorbent (XRDAH203).

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UCT Flagship Sorbent Clean Screen® DAU cited in new Fentanyl/Opioids Analogs Paper

Since the introduction of Fentanyl as a legitimate medication, UCT has been at the forefront of assisting forensic toxicology facilities with the finest solid-phase extraction (SPE) sorbents and methodologies to extract and concentrate the drugs efficiently. With the recent emergence of newer potent analogs in the illicit community, UCT has expanded upon its existing sample preparation methods to include these novel, structurally similar derivatives. In a new paper authored by E.N.Shoff et al., published in Journal of Analytical Toxicology (doi: 10.1093/jat/bkx041), the determination of fentanyl analogs and other opioids in postmortem cases is thoroughly detailed employing Clean Screen® DAU solid-phase extraction cartridges as an integral part of this methodology. 

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UCT Silane (DETA) cited in bio-physiological research paper

UCT is widely recognized as the premier manufacturer of specialty chemicals by researchers working in the area of biological analysis and modeling. This is exemplified by a paper published in Biomaterials by X.Guo et al.,  ((2017) 122 179-187).  In their study,  they report the de novo induction of human intrafusal skeletal muscle fibers from satellite cells and their synaptic connection with human stem cell-derived sensory neurons in a defined in vitro system. As an integral part of the study, process microscope coverslips were coated with UCT’s silane trimethoxysilylpropyldiethylenetri-amine (DETA, T2910KG) and were used to produce a film by the reaction of the cleaned surfaces with a 0.1% (v/v) mixture of the organosilane in freshly distilled toluene. This film was employed to study the induction of intrafusal fibers which were characterized by morphology and fiber-type specific transcription factor expression using phase microscopy and immunocytochemistry.

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UCT Clean Screen® ZSDAU020 cited in Synthetic Cathinones Study

UCT is recognized around the world for its outstanding support of forensic toxicologists/ toxicology facilities and understanding the many challenges that face analysts on a day to day basis. Some of the major obstacles are the extraction and analysis of new synthetic cathinones in blood by GC-MS. In a recent paper published in Analytical Methods ((2017) 9 2732) by K. A. Alsenedi and C.Morrison, samples of whole blood were extracted using UCT’s flagship sorbent Clean Screen® ZSDAU020 and eluted with a methylene chloride-isopropanol-ammonium hydroxide solution. Following evaporation, the residues were modified with six acylation reagents and compared for their derivatization potential. 

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UCT Clean Screen® FASt (Filter & Shoot) Cartridge Cited in New Drug (Tianeptine) Case Study

UCT in recognized around the world not only for manufacturing the finest solid phase extraction (SPE) sorbents, but also providing scientific support for clinical and forensic toxicology accounts worldwide. UCT’s FASt (Filter & Shoot) sorbent has recently been utilized in the analysis of the novel pharmaceutical tianeptine in forensic toxicological urine samples by S.K Dempsey et al., in Journal of Analytical Toxicology (doi: 10.1093/jat/bkx034) .

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UCT Silane Cited in Novel Separations Article

UCT is world renowned as the premier manufacturer of the finest specialty chemicals including silanes and siloxanes. Researchers in the field of separation science looking to advance the boundaries require the finest of materials for their studies. In a recent paper authored by Patrizia Simone et al., (Journal of Chromatography A ((2017) 1498, 46-55) a UCT silane (N-trimethoxysilylpropyl)-polyethylenimine was utilized as an important reagent in the production of a monolith for separations of small molecules and intact proteins.

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UCT's ChloroFiltr® cited in Agrochemical Paper

UCT is recognized around the world as the first company to commercialize the use of the QuEChERS technique for use in pesticide and herbicide analysis. While supplying a large diversity of commonly available clean-up sorbents, UCT is sole supplier of ChloroFiltr®, a novel polymeric based sorbent designed for the removal of chlorophyll from acetonitrile extracts without compromising on the recovery of planer pesticides.

In a recent paper published in Environmental Science and Technology Letters by E.M.Peterson et al., (DOI: 10.1021/acs.estlett.7b00123), ChloroFiltr®  is put to use for the analysis of neonicotinoids on wildflowers close in proximity to cattle feed yards. 

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Recognizing UCT's Latest Intern - Stephanie Oddi

Recently Arcadia University's Forensic Science Program did an Internship Spotlight on Stephanie Oddi, UCT's 2016-2017 intern. We would like to share her feedback from her experience here below and also thank her for all the valuable time and contributions she has provided to our internal R&D efforts. Best of luck Stephanie as you move forward in the forensic community! We wish you nothing but the best - From Your UCT Mentors!

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Clean Screen ® DAU cited in U.S. Medical Examiner Heroin Article

Over the past two decades, prescription and illicit opioid use has led to changes in public health policy to address the increasing number of opiate/ opioid-related deaths. UCT's flagship sorbent, Clean Screen® DAU, is recognized as the finest solid phase extraction (SPE) sorbent for opiate/opioid extraction and analysis from biological samples. In a new paper published in Journal of Forensic Sciences (House Publication of American Academy of Forensic Sciences) JFS doi: 10.1111/1556-4029.13511 by Love et al., cases submitted for analysis to Hennepin County Medical Examiner’s Office between 2004 through 2015 were extracted utilizing UCT's DAU column, where heroin was identified as a significant contributor or as the primary cause of death.

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Join UCT at Emirates Forensic!

UCT is pleased to be attending for the first time Emirates Forensic, the Middle East region’s largest event on Forensic Science and Forensic Medicine. Emirates Forensic will be held from 2nd to 4th of April 2017 in Sheikh Maktoum Hall of the Dubai International Convention & Exhibition Centre. The show is being organized by INDEX Conferences & Exhibitions Org. Est along with its strategic partner, Dubai Police. Stop by BOOTH A05 to learn more about UCT's latest product offerings and collaborations. 

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UCT SPE Sorbent cited in Ractopamine Method Validation Paper

UCT is known in the industry as the premier manufacturer of Solid Phase Extraction (SPE) sorbents. Many of these clean-up products are commonly utilized in the food safety and public protection markets, for example in the detection of Ractopamine (RAC) in animal feed. RAC is a phenylethanolamine that has been approved for use as a feed additive in some countries to enhance leanness in animal selected species. It is used with the purpose of increasing the rate of weight gain, improving feed efficiency and increasing carcass leanness. Despite these benefits, the use of RAC has been related to adverse effects in cardiovascular and central nervous systems of animals and consumers. In a paper authored by Caldeira et al., published in the journal Accreditation and Quality Assurance ((2017) 22,91–96), an analytical method was developed and validated based on extracting RAC with acetate buffer, hydrolyzing with β-glucuronidase and a purifying by SPE using UCT’s world renowned flagship SPE sorbent Clean Screen® DAU. 

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Check out UCT's new technical article in Chromatography Today, "A Modified QuEChERS Approach for the Extraction of Common Prescription and Illicit Drugs from Liver Prior to LC-MS/MS Analysis."

Preliminary studies have shown that the QuEChERS technique should be considered as a reliable alternative when extracting multiple drug classes from challenging biological matrices. The project described here, explores a modified universal QuEChERS approach for sample clean-up in post-mortem liver, coupled with LC-MS detection, for the analysis of several common prescription and illicit drugs. Read more here

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UCT Specialty Chemical (TSPS) cited in Clinical Chemistry Article

UCT is known around the world as the premier manufacturer of the finest specialty chemicals used in the field of clinical research. In a recent paper published in Plos One (12(2): e0171915. doi:10.1371/journal.pone.0171915) by R.Jension et al., “A novel approach to eliminate detection of contaminating Staphylococcal species introduced during clinical testing”, UCT’s T-structure polydimethylsiloxane (TSPS) was used to coat crystalline wafers used in the procedure. This chip utilizes TSPS as a specialty chemical integral to the process. 

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Strawberries remain at top of pesticide list, report says.

The recently released annual report by the Environmental Working Group found that nearly 70% of samples of 48 types of conventionally grown produce were contaminated with pesticide residues. This year, strawberries remained at the top of the list of produce with the highest concentration of pesticides, while sweet corn and avocados were ranked as having the lowest concentration.  For all your pesticide residue detection needs visit https://sampleprep.unitedchem.com/products/quechers. To read more about the recently released report, click here

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UCT’s Flagship Sorbent (ZSDAU020) cited in Remifentanil article

UCT is recognized for its support for the forensic toxicology community not only domestically, but abroad. This is demonstrated in a new article published in the journal Toxicologie Analytique & Clinique authored by Dr.J Long et al.,(http://dx.doi.org/10.1016/j.toxac.2016.11.003 2352-0078). In this paper, the authors utilize UCT’s famous Clean Screen ® DAU solid phase extraction column (ZSDAU020) to extract remifentanil, a short acting fentanyl analogue, from post mortem blood samples. This is believed to be the first report of a concentration of remifentanil in postmortem blood.

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Check out UCT's new article "QuEChERS 101" live on Cannabis Industry Journal today.

The piece documents a brief history of the QuEChERS extraction method and its application in pesticide residue testing for cannabis. Read more here: https://lnkd.in/dhUaURg

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UCT QuEChERS cited in Food Protection Paper

UCT is world renowned for its support for analysts and scientists working in the area of environmental food protection for the public utilizing any of our Solid Phase Extraction (SPE) or QuEChERS (“quick, easy, cheap, effective, rugged and safe”) sorbents and pre-packed pouches. In a recent paper by L. Han et al., working with Dr. S. Lehotay at US Department of Agriculture, Agricultural Research Service (USA) in the journal Food Control (2016) 66 27-282),  an easy and reliable high-throughput analysis method was developed and validated for 192 diverse pesticides and 51 environmental contaminants (13 Polychlorinated biphenyls (PCB) congeners, 14 Polyaromatic hydrocarbons (PAHs), 7 Polybrominated diphenyl ethers (PBDE) congeners, and 17 novel flame retardants) in cattle, swine, and poultry muscle.

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UCT Enviro Clean® SPE Columns Cited in N-nitrosodimethylamine (NDMA) Paper

UCT Inc., is known around the world as the premier manufacturer of Solid Phase Extraction (SPE) sorbents. It’s support for analysts performing testing in the field of environmental sample testing for public protection has been a core activity for over thirty years. In a recent paper published in Environmental Science Water Research & Technology ((2016), 2, 502) by D.L.McCurry et al., UCT’s Enviro Clean® activated carbon SPE columns were employed to extract and analyze NMDA from water.

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Visit UCT at the 3rd Annual 2017 Emerald Conference February 2nd-3rd

UCT is proud to support Emerald Scientific’s 2017 annual conference which is devoted to the deep exploration and discussion of the science of cannabis, including analytical testing, extraction and infusion sciences, cultivation sciences, clinical applications, inter-lab comparison and proficiency testing, state regulations, industry standardization, and more.  Please join us all week at BOOTH 132 to learn more about our latest product offerings including QuEChERS products and well-plates geared towards the analysis of cannabis and edible products, Selectra® HPLC columns, GC liners, Selectra-Sil® Dervatizing Reagents, and Ultra Flash® Flash Chromatography Purification offerings. 

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UCT Enviro Clean QuEChERS and SPE cited in Food Analysis Paper

In the agricultural community, there are thousands of pesticides that could be potentially used to protect crops. In a recent paper published in Journal of Food and Agricultural Chemistry (J. Agric. Food Chem. (2017) 65, 473,493) by J.Wang et al., (Canadian Food Inspection Agency, Calgary, Canada), UCT’s Enviro Clean QuEChERS Pouches were used in conjunction with Enviro Clean 15mL dSPE centrifuge tubes for targeted screening of 448 pesticide residues in fruits and vegetables.

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UCT to Attend 2017 MSACL in Palm Springs!

UCT is excited to participate in the 9th Annual MSACL Conference & Exhibit. Stop by BOOTH 1 to learn about all our latest product offerings and collaborations, including our HPLC columns, QuEChERS products geared towards the analysis of cannabis and edible products, Abalonase®/ Abalonase®+ Purified Beta Glucuronidase, as well as our full line of sample preparation products, reagents, and accessories.

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UCT Silane cited in Biomaterials Paper

UCT Inc., is highly regarded by researchers in the area of biomechanical analysis for the manufacture and production of the very finest specialty chemicals including silanes and siloxanes. In a new paper by Prof. J.Hickman et al., NanoScience Technology Center, University of Central Florida (Journal of Biomaterials (10.1016/j.biomaterials.2017.01.005)), UCT’s specialty chemical trimethoxysilylpropyldiethylenetriamine (DETA, T2910KG) was employed to produce a film on microscope slides. These slides were then used for the induction of human intrafusal skeletal muscle fibers from satellite cells and their synaptic connection with human stem cell-derived sensory neurons in a defined in vitro system.

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UCT QuEChERS Kits Cited in the Analysis of Asian Style Sauces

UCT is known around the world as the first company to commercialize the QuEChERS ((Quick, Easy, Cheap, Effective, Rugged, and Safe) approach and is proud to support facilities involved in food safety testing using this technique. In a new paper published in Journal of Agricultural and Food Chemistry (DOI: 10.1021/acs.jafc.6b05051) by S. Genualdi et al., (U.S. Food and Drug Administration, Maryland, USA) the simultaneous analysis of 3- monochloropropane-1,2-diol (3-MCPD) and 1,3 dichloropropane-2-ol (1,3-DCP) was executed in asian style sauces. In this report UCT’s extraction mylar pouches (AOAC Blend) which include 6 g MgSO4 with 1.5 g of sodium acetate and dSPE clean-up pouches containing 400 mg of PSA and 400 mg of C18 were employed to perform the QuEChERS extraction prior to analysis of 3-MCPD and 1,3-DCP. This new method utilized direct analysis of the extract without derivatization using gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS). The developed method was applied to 60 genuine soy sauce samples to determine if concentrations have changed since the FDA limit was set in 2008.

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UCT Clean Screen® DAU columns cited in Pharmacology Paper

UCT is known around the world for its support of clinical pharmacologists and their studies as they look for the finest sorbents to perform the extractions.  In a recent paper by Adam L. Halberstadt  (Department of Psychiatry, University of California San Diego), UCT’s flagship sorbent Clean Screen® DAU (ZSDAU020) was employed in the study involving the interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine (Pharmacology, Biochemistry and Behavior (2016) 143 1–10).Monoamine oxidase inhibitors (MAOIs) are often ingested together with tryptamine hallucinogens, but relatively little is known about the consequences of their combined use.

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Clean Screen® THC Sorbent Cited in THC-COOH Validation Paper

Of all the analytical methods available to forensic toxicologists, testing for cannabinoids is one most requested extraction approaches via the technical support team.  In a recent paper authored by Nicolas Fernandez et al., from Universidad de Buenos Aires published in Acta Toxicol. Argent. ((2016) 24 (2): 116-127) UCT’s world famous Clean Screen® THC was employed as the extraction sorbent in an accurate, reproducible, and validated gas chromatography-mass spectrometry (GC-MS) method for the quantitation of 11-nor-9-carboxy- Δ9 -tetrahydrocannabinol (THCCOOH), the major metabolite of Δ9 -tetrahydrocannabinol in urine.

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UCT QuEChERS cited in Perfluoroalkyl Substances Paper

UCT QuEChERS cited in Perfluoroalkyl Substances Paper - PFAS's have recently received increased research attention, particularly concerning aquatic organisms in regions of exposure to Aqueous Film Forming Foams (AFFFs). In a paper recently published in Environmental Toxicology and Chemistry (DOI: 10.1002/etc.3726) by H.A. Lanza et al., (Texas Tech University, Lubbock, Texas, USA) six PFASs, including perfluorooctane sulfonate (PFOS), were extracted from whole fish composites via UCT QuEChERS extraction kits. 

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Top 10 Forensic Compounds/Topics of 2016 - Coming Soon - QuEChERS Technique for Handling Post-Mortem Matrices

In 2003, the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method was developed as a way to improve conventional sample preparation for multi-residue pesticide analysis in a variety of difficult matrices. While the methodology was initially invented for the food testing industry, it has recently caught the attention of several other types of analytical laboratories including the post-mortem drug testing communities. 

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Top 10 Forensic Compounds/Topics of 2016 - Designer Benzodiazepine Analysis

Compared to other classes of drugs, benzodiazepine abuse is relatively uncommon. However, there has been an upward trend of using them along with other drugs, such as alcohol and opioids, in order to achieve an enhanced overall high. 

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Top 10 Forensic Compounds/Topics of 2016 - Synthetic Cannabinoid Analysis

The number of products marketed as “legal alternatives to cannabis” or “legal highs” have dramatically increased in popularity in recent years. It can be a real challenge for testing labs to keep up with the new, synthetic cannabinoids. Although these compounds are ever-changing, they are derived from “template structures”, which are ideal candidates for clean-up via solid phase extraction (SPE).

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Top 10 Forensic Compounds/Topics of 2016 - Oral Fluid Analysis

It’s no surprise that oral fluid drug testing has gained recent popularity in forensic and clinical laboratories. Not only is it easier to acquire from a sample collection perspective, but also, it’s much less invasive when comparing the measures utilized to solicit urine and blood samples. 

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Top 10 Forensic Compounds/Topics of 2016 - Identification and Extraction of Fentanyl and Its Newly Emerging Analogues

It goes without saying that fentanyl related overdoses and deaths were a major public health issue across the United States in 2016 and will continue to be in the upcoming year.  Forensic toxicologists need fast and accurate extraction methodologies in order to not only identify fentanyl but also additional novel analgesics that may be isolated in casework screening protocols.  

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Top 10 Forensic Compounds/Topics of 2016 - Cannabis Analysis

Even within states where recreational cannabis has not been legalized, government funded crime laboratories are seeing an uptick in seized plant and edible cannabis cases.  While toxicology sections are equipped with the tools needed to extract said samples if tasked with this additional work, drug chemistry units may struggle to treat the various edible forms, tinctures and waxes that appear in their laboratory.  

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Top 10 Forensic Compounds/Topics of 2016 - Opiate Derivatization

Multiple strategies can be used to derivatize opiates prior to analysis on GC-MS.  A variety of both silylation and acylation reagents can be used to best accomplish this, including either BSTFA (with 1% TMCS) or Propionic Anhydride (PIA).  

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Top 10 Forensic Compounds/Topics of 2016 - Enzyme Hydrolysis Rates for Opiates

The hydrolysis of morphine-3-glucuronide and various other conjugated drug classes such as benzodiazepines and synthetic cannabinoids is routinely fast and efficient. Other compounds prove to be more difficult to covert, such as codeine-6-glucuronide, due to the nature of the chemical bonds at hand and the configuration of the enzyme to the substrate.  

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Top 10 Forensic Compounds/Topics of 2016 - Baseline LC Separation of Isobaric Compounds

The ability to separate complex mixtures of structurally similar compounds within one method is highly desirable. Additionally, compounds of related structures may also be isobaric with similar fragmentation, rendering them unidentifiable by MS/MS. In these cases, it is essential that these compounds be baseline separated chromatographically. 

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Top 10 Forensic Compounds/Topics of 2016 - The Analysis of Δ9-THC and Its Main Metabolites in Whole Blood

While these compounds have been major players in a toxicological setting for quite some time, there still appears to be a generalized struggle to precipitate and extract them efficiently from whole blood. Not only is the ratio of acetonitrile to blood sample critical for proper precipitation of these highly protein-bound compounds, but also the speed in which it’s added along with the working temperature of the solvent at hand. 

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Top 10 Forensic Compounds/Topics of 2016 - EtG/EtS Analysis in Urine

Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are conjugated ethanol biomarkers.  Due to their highly polar nature (log P of 1.51 and 0.62, respectively) and lack of retention on a traditional reversed phase HPLC column, their analysis is typically plagued by significant ion suppression when using a standard Dilute & Shoot approach.

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Opioid overdoses are nearing record levels in the city that's become a 'mecca' for addicts

"During the first weekend of December, nine people died of apparent drug overdoses in and around Kensington, a neighborhood in northern Philadelphia. Those deaths came just weeks after the city, which has become a "mecca" for addicts, saw 50 overdoses — five of them fatal — in one day on November 17. Philadelphia, and the neighborhood of Kensington in particular, has become a focal point for the US's deepening opioid crisis. " Read More Here: http://www.businessinsider.com/opioid-heroin-fentanyl-overdose-crisis-philadelphia-2016-12

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UCT Silanization Reagent Cited in Capillary Monolith Paper

UCT Inc., is known around the world for the manufacturing of the very finest in specialty chemicals including (N-trimethoxysilylpropyl)-polyethylenimine. These compounds are regularly employed by researchers in fields such as the production of methacrylate-based monoliths for highly efficient separations. In a recent paper published in Journal of Chromatography A by P. Simone et al., (Sapienza Università di Roma, Italy (http://dx.doi.org/10.1016/j.chroma.2016.11.039)) capillary methacrylate-based monoliths were prepared for the high performance liquid chromatography (HPLC) separation of both small molecules and large biomolecules. An efficient grafting from/to synthetic approach was adopted introducing a network of activated sites in the inner wall surface using the new silanization agent (N-trimethoxysilylpropyl)-polyethylenimine obtained from UCT.

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UCT Styre Screen® THC Columns cited in Cannabinoids Paper

UCT is well recognized in the analytical testing field for manufactoring the finest silica and polymeric based sorbents. Most recently, The Styre Screen ® SPE column line has been utilized in a paper authored by R.C. Kevin et al., (University of Sydney, Australia) in the journal Forensic Toxicology (doi:10.1007/s11419-016-0330-0) where urinary cannabinoid concentrations were measured during nabiximols (Sativex®)-medicated inpatient cannabis withdrawal. The hydrolysed samples containing (CBD, THC, THC-COOH, and 11-OH-THC) were directly loaded onto Styre Screen® (SSTHC063) SPE columns.  This paper demonstrates the efficiency of UCT’s polymeric Styre Screen® sorbents in the analysis of cannabinoids, and why researchers working in the field of cannabinoid analysis turn first to UCT for the finest in silica and polymeric sorbents. 

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UCT SPE Cartridges cited in Equine Toxicology Study

In the fields of both human and animal toxicology, UCT Inc., is world renowned for its manufacture of the finest SPE sorbents. This is most eloquently demonstrated in an article published in Journal of Veterinary Pharmacology and Therapeutics ((2016) 39, 469–477) by H.K. Knych et al., (UCSF, Davis) detailing the pharmacokinetics of methocarbamol and phenylbutazone in exercised thoroughbred horses. Methocarbamol (MCBL) commonly used in performance horses for the treatment of skeletal muscle and  phenylbutazone (PBZ), another commonly used drug in performance horses, were both extracted and analyzed using UCT’s flagship sorbent Clean Screen®DAU (CSDAU 130 mg/3 mL). This paper shows that when researchers working in the area of equine toxicology need the finest SPE sorbents for their extractions, they routinely turn to UCT as their first choice.

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Thanksgiving Holiday

UCT will be closed for the holidays on November 24th-25th. Normal business hours will resume on Monday, November 28th. We wish you the happiness of good friends, the joy of a happy family, and the wonder of the holiday season. Have a memorable Thanksgiving!

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Happy Veteran's Day to our honorable service men and women from all of us at UCT!

As we express our gratitude, we must never forget that the highest appreciation is not to utter words, but to live by them - President John F. Kennedy

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UCT Silane used in Cellular Modeling

In the field of bio-mechanical research, scientists working in the field of cellular modeling require the finest of specialty chemicals in order to produce world class studies. UCT Inc., is known around world as a premier manufacturer of Silanes and Siloxanes.

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Check Out UCT's New Cannabis Technical Article 'Determination of Cannabinoid Content and Pesticide Residues in Cannabis Edibles and Beverages' on LCGC!

http://www.chromatographyonline.com/determination-cannabinoid-content-and-pesticide-residues-cannabis-edibles-and-beverages

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Trick or Treat!

Happy Halloween from all of us at UCT!

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UCT Silane Cited in Microfluidic Article

UCT has long been recognized for the support of research bio-pharmaceutical scientists working on micro-fluidics through its Specialty Chemical line producing the finest of silanes in the market place. In a recent paper by Kim et al., based at Texas A&M University, USA (Micromachines (2016), 7, 114; doi:10.3390/mi7070114) used UCT's tridecafluoro-1,1,2,2-tetrahydrooctyl trichlorosilane in their procedure to produce a microfluidic unit.

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UCT SPE Columns Cited in Illicit Fentanyl Fatalities Paper

One of the more recent prescription drugs being abused illicitly is Fentanyl. This compound induces pharmacological effects and abuse liability comparable to other prescription opioids and heroin. A surge in fentanyl-related fatalities has been periodically reported throughout the USA. In an article published in the Special Issue of the Journal of Analytical Toxicology (JAT) by a team lead by Prof. B. A. Goldberger ((2016) 40:588–594), UCT’s flagship sorbent Clean Screen® DAU was employed to extract and analyze post mortem blood samples for fentanyl. 

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Join UCT at CANNCON 2016!

UCT is proud to support Canncon’s 2016 annual conference which unites cannabis industry experts, instrument manufacturers, testing labs, research scientists, medical practitioners, policy makers and interested novices. Please join us all week at  BOOTH 100 and several other educational platforms to learn more about our latest product offerings

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UCT Xtrackt® SPE Cited in Equine Drug Testing Paper

The compound list for forensic and animal toxicologists to identify, confirm and quantify is constantly increasing. In a recent paper published in Analytical Methods ((2016, 8: 1789) Cawley et al., used UCT’s Xtrackt ® SPE column to isolate 2,5-dimethoxy-N- (2-methoxybenzyl)phenethylamine (NBOMe) compounds from samples of equine urine in a  validation study to develop a workflow procedure developed for non-targeted analysis using  a commercial differential analysis software platform. 

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DEA Notice on New Drugs

UCT is well known for its support of the forensic toxicology community across the globe. With this in mind, UCT notes that  USA's Drug Enforcement Administration is placing the substance thiafentanil (4-(methoxycarbonyl)-4-(N-phenmethoxyacetamido)-1-[2-(thienyl)ethyl]piperidine), including its isomers, esters, ethers, salts and salts of isomers, esters and ethers into Schedule II of the Controlled Substances Act effective 26 August 2016. 

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UCT Launching Ultra-Flash Purification Line at 2016 ACS Meeting!

UCT is excited to participate in the 252nd American Chemical Society National Meeting & Exposition from Aug 21-23rd at the Philadelphia Convention Center. Stop by BOOTH 306 to learn about our 2016 newly launched Ultra Flash® Purification columns! UCT will be featuring 3 distinct lines: standard silica/bonded phase columns, ILOK® format columns conducive for manual assembly and column stacking, and, most notable, our spherical high pressure columns rated up to 400 psi. Our Ultra Flash® Purification line is 100% leak-free, 100% compatible with all flash instrumentation currently in the marketplace, and provided in an extensive range of sizes. Stop by to learn more!

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UCT's Putting a New Spin on dSPE!

UCT is excited to launch our new SpinFiltr™ approach to dSPE clean-up!  Our dual chamber approach features built in submicron filtration and allows the user to simply discard the top device containing unwanted matrix and sorbent following centrifugation. Additional sample volume is recovered without worrying about the disruption of centrifugation layers. UCT is taking the hassle out of dSPE. Try a sample today out of our initial 5 available configurations! Get more details by visiting: https://sampleprep.unitedchem.com/media/at_assets/tech_doc_info/SpinFiltr_Flyer_2016_1.pdf or by checking out our recent NACRW poster presentation featuring this product: https://sampleprep.unitedchem.com/media/at_assets/tech_doc_info/NACRW_Poster_2016.pdf

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Clean Screen THC SPE Column cited in a 2-Year Study of THC Concentrations in the Blood of Drivers in Orange County California

The Clean Screen® THC solid phase extraction (SPE) column is UCT’s flagship THC sorbent. In a paper authored by Declues et al., (Journal of Forensic Sciences (doi: 10.1111/1556-4029.13168)) the Clean Screen THC columns were employed to analyze 1204 whole-blood samples confirmed to contain THC alone or in combination with other drugs out of nearly 5000 Orange County, California drivers suspected of driving under the influence of drugs in a extended time period. The limit of quantification (LOQ) for both THC and carboxy-THC was determined  to be 2 ng/ mL in whole blood. This study using genuine drugs and driving cases demonstrates why forensic toxicologist turn time and time again to UCT’s finest sorbents for their analyses.

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Clean Screen® DAU SPE Cited in Bathsalts Paper

One of the most difficult challenges facing forensic toxicologists is the extraction, analysis and quantification of  synthetic cathinones. In a paper published in Journal of Analytical Toxicology (JAT) by Peters et al., from East Tennessee University (doi: 10.1093/jat/bkw074), UCT’s flagship SPE Clean Screen® DAU was employed to extract the bathsalts from rat brain tissue. This article demonstrates the power of the Clean Screen®DAU to assist forensic toxicologists in efficiently extracting newer psychoactive compounds from very complex matrices.  

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World's Most Popular Pesticide Cuts Bee Sperm 39 Percent, Study Says

For years, people have wondered what's killing the bees as populations of the fuzzy pollinators critical to the global food chain have fallen off. They've racked up declines of 27.4 to 42.1 percent since 2013, well above the 18.7 percent loss the USDA says is the maximum for being economically sustainable. Now a new study says it's not that they're being killed, it's that they're not being born. The world's most popular class of insecticides, "neonicotinoid" pesticides actually cuts bee sperm by 39 percent, according to researchers at the University of Bern, Switzerland. 

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Check out UCT's new article on Cannabis Industry Journal entitled, "HPLC Column Selection for Cannabis Chromatographers."

UCT's most recently posted article provides a technical overview of utilizing the appropriate HPLC phase for both potency and pesticide testing in the cannabis industry. Try out one of our recommended Selectra® HPLC columns today!

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Congrats to Greg Mercer from USFDA Pacific Regional Lab for winning the NACRW 2016 "UCT Excellence in Sample Preparation Award"

UCT would like to extend our congratulations to Greg Mercer from the USFDA Regional Pacific Laboratory for winning the 2016 NACRW  "UCT Excellence in Sample Preparation Award." The awarded poster presentation was entitled "A Simple and Effective Cleanup Procedure to Produce Quechers Extracts That Are More Compatible with Gas Chromatography" featuring UCT's Chlorofiltr® dSPE sorbent. This polymeric-based material selectively removes interfering chlorophyll from sample extracts without compromising the recovery of planer pesticides. Try a sample today!

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Determination of Methamphetamine Enantiomer Composition in Human Hair Using Clean Screen® DAU SPE Columns.

One of the issues that face forensic toxicologists is the analysis of chiral drugs especially within the amphetamine type substances (ATS). In a recent paper by I. Shu et al., published in the prestigious Journal of Chromatography B ((2016) 1028:145), methamphetamine was extracted using UCT’s flagship sorbent Clean Screen® DAU from hair samples. By executing an efficient sample clean-up and concentrating the extract, it allowed for the detection of the analytes in question at the concentrations normally encountered in a hair-based matrix.

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UCT Siloxane cited in Split Ring Resonator Research

UCT's Petrarch Specialty chemical line is world renowned for being of the finest quality and employed by scientists working at the cutting edge of electronic engineering research.In a paper published by Fan Zhou et al (Northeastern University) in Optical Express ((2016), 24: 6367) a detailed study was reported into Split ring resonators which employed the use of UCT product poly[(mercaptopropy)methylsiloxane] (PMMS) to fabricate the soft stamps. Browse UCT's selection of high quality specialty chemicals today!

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UCT ZSDAU020 Columns Cited in Methamphetamine Primate Study

Amphetamine-type stimulants, including methamphetamine, are the world's second most commonly used illicit drug (surpassed only by marijuana), with at least 30 million people using it regularly. In a recent paper published by D.V.Vaupel et al  working with the scientists at National Institute of Drug Abuse (NIDA), UCT's flagship sorbent Clean Screen® DAU (ZSDAU020) was employed to extract and analyze methamphetamine from the whole blood of eight male rhesus monkeys to gain a better toxilogical understanding of the long-term effects of these compounds.

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UCT Silane Cited in Robotic Paper

In the field of human animatronics, the use of specialty chemicals must be of the highest quality due to the degree of precision for the electronics and the engineering that is employed. UCT Inc., is recognized around the world by scientists working in the field of miniaturization of robotics and rightly turn to UCT as the premier manufacturer of the finest specialty silanes. Continue Reading

Fourth of July Holiday Wishes and Closure Notice

Please note that UCT will be closed on Monday July 4th, 2016 in observance of Independence Day. We will reopen Tuesday, July 5th at 8 am EST.

We wish all of our clients a very happy and safe 4th of July holiday.

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UCT Enviro-Clean 521 Columns Cited in Nitrosoamines Study

UCT Inc., is well-known for its commitment to support in the area of environmental analytical research. In a recent paper published  in Science of The Total Environment by J-H Lee and  J-H Oh ((2016) 556: 330-337), UCT’s  Enviro-Clean 521 cartridges were used to extract nitrosoamines from water samples originating in sewerage water plants. 

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UCT Specialty Chemical Cited in Cardiovascular Study

UCT is world renowned for its support of biological research through its specialty chemicals, and in a recent study published in PLOS ONE by S.Chen et al., ( http://dx.doi.org/10.1371/journal.pone.0155681), UCT’s silane  (tridecafluoro-1, 1, 2, 2-tetrahydrooctyl-1 tri-chlorosilane) was employed in the 3D printing process for synthetic replacements for large-diameter blood vessels. 

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The Chinese Connection Fueling America’s Fentanyl Crisis

'The Chinese Connection Fueling America’s Fentanyl Crisis'- Fox News-A vast network beginning in China feeds fentanyl, a deadly synthetic opioid, to the U.S., Mexico and Canada. The opioid epidemic crippling the United States is real! Read more here. https://lnkd.in/dxidvpn
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UCT SPE sorbents and the Newer Psychoactive Compounds (NPS)

Among the challenges that now face forensic toxicologists is the extraction, confirmation, and quantification of synthetic cannabinoids and synthetic cathinones, many of which are new to both the enforcement agencies and analysts alike. UCT is at the cutting edge of not only developing methods/applications for these two emerging classes of compounds, but also supporting forensic toxicologists with their analysis through the use of Silica Clean Screen® THC and DAU sorbents and Styre Screen® polymeric HLD sorbent  These chemical phases can be supplied in 1, 3, 6  and 10 mL formats with 50 to 200 mg bed masses in addition to well plate formats (48/96). 

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Opiate/Opioid Analysis Using UCT SPE Sorbents

The abuse of and addiction to opioids and opiates such as morphine, codeine, and hydrocodone is a serious global problem that affects the health, social, and economic welfare of all societies around the world.  It has been estimated that between 26.4 million and 36 million people abuse opioids worldwide, with an estimated 2.1 million people in the United States suffering from substance use disorders related to prescription opioid pain relievers. UCT has been at the forefront of toxicological analysis of opiates (those compounds originating from the poppy plant), and opioids (compounds structurally related to morphine but produced synthetically e.g hydromorphone, oxycodone, and oxymorphone) using its world renowned Clean Screen® DAU and XtrackT® sorbents.

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UCT featured in a Select Science article, “Update on Water Analysis Methods" with recent release of streamlined EPA 1694 method!

UCT has been featured in a SelectScience article, “Update on Water Analysis Methods" with recent release of streamlined  EPA 1694 method: Analysis of Pharmaceuticals and Personal Care Products in Water.  Check Us Out Here!

 

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Fentanyl Overdose Analysis Executed on UCT SPE Column

There have been 256 fatal overdoses from illicit drugs in the first four months of this year in Canada, already more than half the 480 that occurred for all of 2015. Fentanyl's connection to those deaths has been surging at a staggering rate. As a standard basic drug with a pKa of 8.8, fentanyl is a prime candidate for strong cation exchange SPE on such sorbents as UCT’s flagship cartridge Clean Screen® DAU. Fentanyl's main metabolite, norfentanyl, and its newer analogs such as acetylfentanyl are also favored by this sorbent and corresponding methodology for high quality results.

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UCT Clean Screen GHB Column Cited in Analytical Letters

In this study into GHB analysis, which was published in Analytical Letters ((2016) 49:2 217–225) by Pyo et from College of Pharmacy, Kyungsung University, South Korea, solid-phase extraction (SPE)  was conducted using UCT's Clean Screen GHB SPE columns (CSGHB). The recovery for gamma-hydroxybutyric acid by CSGHB was 64.5– 70.9% compared to 32.6–47.5% by liquid–liquid extraction. SPE using CSGHB also offered shorter analysis time, smaller sample quantities and solvent volumes, and better separation.

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The Use of ZSTHC020 in German Cannabinoids Study

Of all the analytes that Forensic Toxicologists are asked to test for, THC still remains high on the list. In this recent study published in  the International Journal of Legal Medicine (DOI 10.1007/s00414-016-1368-6) from the Institute of Legal Medicine (Muenster, Germany), a procedure employing UCT's Flagship THC SPE column (ZSTHC020)  was developed and validated for analysis of cannabinoids.

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UHPLC/ESI-MS/MS Determination of 187 Pesticides in Wine using UCT QuEChERS Products

In this recently published journal by Wang and Cheung in the world respected journal J.AOAC International (Volume 99, Number 2, March-April 2016, pp. 539-557(19) ) a quick, easy, cheap, effective, rugged, and safe (QuEChERs) method for extraction of  187 pesticides in both red and white wine samples is presented using ultra-HPLC for the analysis of a wide range of pesticides.  The pesticide residues were extracted from wine samples by a QuEChERS approach  employing  UCT's  ENVIRO CLEAN salts/sorbents. 

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UCT featured in Select Science article, “11 Methods to Ensure Food Safety.”

UCT has been featured in Select Science article, “11 Methods to Ensure Food Safety” with the recently released 'Patulin Analysis in Apple Juice' application. View the Select Science featured article and patulin application note here: http://bit.ly/1Vx47BT

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Clean Screen® DAU Columns Utilized in Characterization of Oxycodone and Metabolites in Human Hair

An article titled, ‘The Disposition of Oxycodone and Metabolite in Human Hair’ was recently published in the Journal of Analytical Toxicology (DOI:10.1093/jat/bkv076). 

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Thank you for attending our booth at NACRW 2015!

UCT would like to extend a special thanks to all of this year’s attendees at NACRW who paid visit to the booth and/or attended our sponsored lunch and learn focused on veterinary drug residue analysis. 

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UCT presenting poster at the American Association of Clinical Chemistry

This year’s annual meeting of the American Association of Clinical Chemistry (AACC) is being held from July 26-30 in Atlanta, Georgia.  The AACC show is the premier event for researchers and analysts in the clinical chemistry field. 

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Minnesota is the latest state to offer legalized medical marijuana

Beginning July 1, 2015 patients in Minnesota will be able to begin to fill prescriptions for medical marijuana.  The Minnesota law is one of the more restrictive nationally, with the cannabis only being able to be taken in pill, oil or liquid form.

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UCT preparing to open first international office and manufacturing site in Wexford, Ireland

UCT, Inc has seen tremendous growth internationally over the past decade.  As part of efforts to better serve its channel partners and customers, UCT began exploring opportunities to expand its physical presence internationally.

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Petrarch® silane used in the manufacture of a custom microchip used in the study of CNS axon growth

In a recent publication titled A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments, Journal of Neuroscience Methods,221, (2014) 166-174, (doi:10.1016/j.jneumeth.2013.09.018) tridecafluoro-1, 1, 2, 2- tetrahydrooctytrichlorosilane (T2492) from UCT Specialties, LLC was used to vapor coat cast molded poly(methylmethacrylate) and PDMS parts.

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World Health Organization highlights food safety

is year the World Health Organization (WHO) dedicated the World Health Day to highlight the importance of food safety. World Health Day is celebrated annually on April 7 to mark the 1948 founding of the WHO.   The theme was, “Food Safety: From Farm to Plate, Keep it Safe” highlighted the importance of keeping food safe throughout the supply chain.

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Clean Screen DAU Columns used in the analysis of ethylone related deaths

Researchers at the University of Florida, led by Dr. Bruce Goldberger, recently published an article in the Journal of Analytical Toxicology (DOI: 10.1093/jat/bkv053).  The paper investigates nine postmortem cases in which ethylone, a synthetic cathinone, was identified.

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UCT Receives ISO Certification

UCT has consistently produced high quality and reproducible organosilicon products.  That commitment was ensured through rigorous manufacturing and quality assurance programs.  Today we are pleased to announce that the system’s upon which our quality is based have been rewarded.

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CBS News report focuses on pesticide residues found in marijuana plants in the state of Colorado

CBS News recently reported that the state of Colorado is stepping up enforcement of testing and quarantining marijuana plants contaminated with banned pesticide materials.

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Clean Screen® DAU Columns in Zolpidem urinary metabolite detection study

An article titled, ‘Determining Zolpidem Compliance: Urinary Metabolite Detection and Prevalence in Chronic Pain Patients’ was recently published in the Journal of Analytical Toxicology (DOI: 10.1093/jat/bku068).

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Dextromethorphan and Dextrorphan Recovery from Skeletal Tissue Investigated

Researchers at Laurentian University (Ontario, Canada), led by Dr. James Watterson, have recently published an article examining the recovery of dextromethorphan and dextrorpan from skeletal tissue.

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Petrarch® Silanes from UCT Specialties Used for QuEChERS Products Research Investigation

In a recently published paper, Chromatographia, DOI 10.1007/s10337-014-2726-5, researchers at the University of Campinas, Sao Paulo, Brazil compared different sorbents in the QuEChERS technique.  The article is titled, “Comparison of Different Sorbents in the QuEChERS Method for the Determination of Pesticide Residues in Strawberries by LC–MS/MS.”

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Petrarch® Specialties Bio-Conext Material Used in Isolating Strains of Con A and E. Coli

In the article ‘Dye-Doped Silica Nanoparticles as Efficient Labels for Glycans’ published in the Journal for Chemical Communications (supplementary information),  The Royal Society of Chemistry2011, DOI: 10.1039/C0CC05299J. UCT Specialties Product, PSX1050  -  (3-Trimethoxysilyl)butylaldehyde  - was used to isolate strains of Con A and E.Coli on lectin microarrays.

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Endcapped C18 Helps Researchers Achieve Excellent Analyte Sensitivity and Recovery for 131 Drug Residues in Bovine Muscle

Marilyn J Schneider, Steven J Lehotay, and Alan R Lightfield at the US Department of Agriculture recently published a paper in the journal Analytical and Bioanalytical Chemistry.

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CLEAN SCREEN® THC SPE Columns Used for the Extraction of 37 Synthetic Cannabinoid Metabolites

Researchers at the Republic of Korea National Forensic Service have recently published an article in the journal of the Japanese Association of Forensic Toxicology titled ‘Simultaneous quantification of 37 synthetic cannabinoid metabolites in human urine by liquid chromatography-tandem mass spectrometry’ (doi 10.1007/s11419-015-0265-x).

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Newly published US EPA method 625.1 allows for solid phase extraction of semivolatile organic pollutants in industrial discharges

The original US EPA method 625 was published many years ago for the analysis of bases, neutrals and acids in municipal and industrial wastewater. The analysis uses liquid-liquid extraction (LLE) and GC/MS detection.

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Selectra® PFPP Column Used in NIDA Paper Examining Cannabinoids in Oral Fluids

Researchers at the National Institute on Drug Abuse (NIDA), led by Marilyn Huestis, PhD, have recently published an article in the journal Drug Testing and Analysis titled ‘Quantification of six cannabinoid metabolites in oral fluids by liquid chromatography-tandem mass spectrometry’ (doi 10.1002/dta1753). 

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UCT Specialties Petrarch® Silanes and crosslinkers used in the study of the dynamic response of transiently trapped entanglements in polymer networks

In a paper recently published, Polymer, 55 (2014) 1061 – 1069, the Dynamic Response of transiently trapped entanglements in polymer networks was studied.

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UCT Specialties Product A0700 (N-(2-Aminoethyl)-3-aminopropyltrimethoxysilane) Used as Coating on Glass Coverslips to Aid in Growth of Mouse ES Cells

In an article published in The Journal of Biological Chemistry, VOL. 288, NO. 47, pp 34168 – 34180, November 22, 2013, Simandlova, et.al., UCT Specialties Product A0700, N-(2-aminoethyl)-3-aminopropyltrimethoxysilane,  was used as a coating on the glass coverslips upon which mouse ES cells were grown and examined.  

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Clean Screen DAU Used for Extraction of Propofol from Blood Samples

Researchers at the Department of Biomedical Engineering at the University of Memphis and Departments of Ophthalmology and Biomedical Engineering at the University of Tennessee have recently published a paper investigating the use of a feedback controlled, closed-loop system for anesthesia. 

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Petrarch® Chemicals Tricholosilane used as a release agent in the development of a microfluidic chip

Kamruzzaman, et.al., developed a microfluidic chip that allowed the detection of L-phenylalanine in pharmaceutical and soft drink products.  This work was reported inFood Chemistry, 135, (2012) 57 – 62.

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Incorporation of Clean Screen FASt® extraction in the study of ZCZ-011in mouse brain tissue helps minimize and stabilize matrix ion suppression effects

Researchers at the Virginia Commonwealth University (Richmond, VA, USA), University of Aberdeen (Aberdeen, U.K.) and the University of Toronto (Toronto, Canada) have developed a novel pharmacological tool for the investigation of the cannabinoid receptor in mouse brain tissue using HPLC-MS-MS analysis.

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