Top 10 Forensic Compounds/Topics of 2016 – Baseline LC Separation of Isobaric Compounds

ByUCT

The ability to separate complex mixtures of structurally similar compounds within one method is highly desirable. Additionally, compounds of related structures may also be isobaric with similar fragmentation, rendering them unidentifiable by MS/MS. In these cases, it is essential that these compounds be baseline separated chromatographically. Several compound duos that require baseline separation for accurate quantitation have been successfully resolved using UCT’s Selectra® DA HPLC column including 2C-phenethylamine isomers, Ephedrine and Psuedoephedrine, Methamphetamine and Phentermine, and Ethylone and Butylone. By choosing the correct column chemistry, mobile phase combination and gradient, baseline separation can be accomplished when needed.

Similar Posts

UCT Xtrackt® SPE Columns Cited in Horse Steroid Analysis Article

UCT Xtrackt® SPE Columns Cited in Horse Steroid Analysis Article

ByUCT

In the field of animal sports toxicology, UCT is recognized around the world as the premier manufacturer of the finest sorbents for the extraction of steroids and other doping agents in equine urine. In a recent paper published in Journal of Pharmaceutical and Biomedical Analysis by H.D.Shin et al., (doi= 10.1016/j.jpba.2017.06.036) a high throughput method for simultaneous screening of anabolic steroids and their metabolites (4-esterendione, trenbolone, boldenone, oxandrolone, nandrolone, methandrostenolone, testosterone, 1-androstendione, ethisterone, normethandrolone, methyltestosterone, 16β-Hydroxystanozolol, epitestosterone, bolasterone, norethandrolone, danazol, stanozolol and androstadienone) in equine urine was developed using UCT’s large particle Xtrackt® SPE sorbent (XRDAH203).

Pharmacokinetic Evaluation of a Cannabidiol Supplement in Horses
| |

Pharmacokinetic Evaluation of a Cannabidiol Supplement in Horses

ByUCT

A new study led by researchers at Oklahoma State University focuses on a better understanding of the pharmacokinetics of orally administered cannabidiol in horses. With the growing popularity of cannabidiol products in the equine industry, it becomes necessary to comprehend the efficacy and pharmacology of such drugs. A low and a high dose of CBD…

UCT SPE Column and Derivatizing Reagent Cited in Warfarin UKIAFT Presentation

UCT SPE Column and Derivatizing Reagent Cited in Warfarin UKIAFT Presentation

ByUCT

UCT’s long chain C30 SPE was employed to analyze drugs in bottlefly larvae. The research aimed to determine whether varying concentrations of warfarin impacts the development of blue bottlefly larvae and to determine whether warfarin levels in this organism can be correlated to drug concentrations in tissues eaten by the larvae. This research was presented by Richard L. Harries et al., at  the UKIAFT annual meeting in Dublin.

UCT Styre Screen® THC Columns cited in Cannabinoids Paper

UCT Styre Screen® THC Columns cited in Cannabinoids Paper

ByUCT

UCT is well recognized in the analytical testing field for manufactoring the finest silica and polymeric based sorbents. Most recently, The Styre Screen ® SPE column line has been utilized in a paper authored by R.C. Kevin et al., (University of Sydney, Australia) in the journal Forensic Toxicology (doi:10.1007/s11419-016-0330-0) where urinary cannabinoid concentrations were measured during nabiximols (Sativex®)-medicated inpatient cannabis withdrawal. The hydrolysed samples containing (CBD, THC, THC-COOH, and 11-OH-THC) were directly loaded onto Styre Screen® (SSTHC063) SPE columns.  This paper demonstrates the efficiency of UCT’s polymeric Styre Screen® sorbents in the analysis of cannabinoids, and why researchers working in the field of cannabinoid analysis turn first to UCT for the finest in silica and polymeric sorbents. 

UCT Clean Screen ®THC cited in Drugs and Driving Study from Orange County, California

UCT Clean Screen ®THC cited in Drugs and Driving Study from Orange County, California

ByUCT

Driving under the influence of drugs (DUID) has become a growing issue nationwide and likewise in Orange County (OC), California. In research published in Journal of Forensic Sciences by K. Declues et al., UCT’s famous Clean Screen® THC SPE cartridges were used to extract cannabinoids from samples of whole blood taken from apprehended drivers in OC over a two-year period. In this study (Part II of a two stage study), a comparison was conducted of examined objective signs, eye examinations and physiological indicators with their relationship to the presence of identified concentrations of THC. 

Leave a Reply