Please note that UCT will be closed on Monday July 4th, 2016 in observance of Independence Day. We will reopen Tuesday, July 5th at 8 am EST.
We wish all of our clients a very happy and safe 4th of July holiday.
Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micro-patterned substrates, which limits turnover and flexibility of prototyping. In a recent paper authored by Janna C. Nawroth et al., published in Biofabrication ( Biofabrication ((2018) 10 025004), UCT’s silane chemicals were used for soft lithography fabrication of stamps for micro-molding hydrogels. The authors developed a rapid and automated method for large scale on-demand micro-patterning of gelatin hydrogels for organ-on-chip applications using a novel biocompatible laser-etching approach.
UCT would like to extend our congratulations to Greg Mercer from the USFDA Regional Pacific Laboratory for winning the 2016 NACRW “UCT Excellence in Sample Preparation Award.” The awarded poster presentation was entitled “A Simple and Effective Cleanup Procedure to Produce Quechers Extracts That Are More Compatible with Gas Chromatography” featuring UCT’s Chlorofiltr® dSPE sorbent. This polymeric-based material selectively removes interfering chlorophyll from sample extracts without compromising the recovery of planer pesticides. Try a sample today!
In the fields of both human and animal toxicology, UCT Inc., is world renowned for its manufacture of the finest SPE sorbents. This is most eloquently demonstrated in an article published in Journal of Veterinary Pharmacology and Therapeutics ((2016) 39, 469–477) by H.K. Knych et al., (UCSF, Davis) detailing the pharmacokinetics of methocarbamol and phenylbutazone in exercised thoroughbred horses. Methocarbamol (MCBL) commonly used in performance horses for the treatment of skeletal muscle and phenylbutazone (PBZ), another commonly used drug in performance horses, were both extracted and analyzed using UCT’s flagship sorbent Clean Screen®DAU (CSDAU 130 mg/3 mL). This paper shows that when researchers working in the area of equine toxicology need the finest SPE sorbents for their extractions, they routinely turn to UCT as their first choice.
Even within states where recreational cannabis has not been legalized, government funded crime laboratories are seeing an uptick in seized plant and edible cannabis cases. While toxicology sections are equipped with the tools needed to extract said samples if tasked with this additional work, drug chemistry units may struggle to treat the various edible forms, tinctures and waxes that appear in their laboratory.
In a recent paper published in Journal of Analytical Toxicology (doi: 10.1093/jat/bky077), authored by Mohammad Ali Al Saad et al., UCT’s Clean Screen®DAU was employed to extract opiates from whole blood. This method was validated for the simultaneous determination of codeine, morphine, 6-acetylmorphine (6-MAM), hydrocodone and hydromorphone in human blood samples
Motor neurons allow the body to move, speak, and breathe due to the propagation of action potentials between neuron nodes. The space between neurons, known as a node of Ranvier, are protected by a myelin sheath. When these nodes or sheaths, become damaged, they lead to demyelinating neuropathies such as schizophrenia, multiple sclerosis, Guillain-Barre syndrome…
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