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Silane Coupling Agent Modifies the Mechanical Properties of a Chitosan Microfiber
Microfiber materials have been widely used for many applications, in the medical field, such as in sutures. Chitosan fibers, along with chitin fibers, are candidates for similar biofibers due to stronger inherent mechanical properties, however the current synthesis of these fibers, which uses epoxy-based crosslinkers, leads to interruption of the crystalline character of the chitosan,…
Top 10 Forensic Compounds/Topics of 2016 – EtG/EtS Analysis in Urine
Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are conjugated ethanol biomarkers. Due to their highly polar nature (log P of 1.51 and 0.62, respectively) and lack of retention on a traditional reversed phase HPLC column, their analysis is typically plagued by significant ion suppression when using a standard Dilute & Shoot approach.
DAU Sorbent cited in Equine Toxicology Study
In a recent study published in Drug Testing and Analysis (DOI: 10.1002/dta.2378), authored by Heather K. Knych et al, UCT’s Clean Screen® DAU was employed to extract grapiprant following oral administration to exercised thoroughbred horses. Grapiprant is a newly approved non‐ cyclooxygenase inhibiting non‐steroidal anti‐inflammatory drug that has demonstrated efficacy and safety in other species. As long‐term use of these drugs can adversely impact the health of the horse, anti‐inflammatories with a more favorable safety profile are warranted.
UCT Silane Cited in Organ-On-Chip Article
Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micro-patterned substrates, which limits turnover and flexibility of prototyping. In a recent paper authored by Janna C. Nawroth et al., published in Biofabrication ( Biofabrication ((2018) 10 025004), UCT’s silane chemicals were used for soft lithography fabrication of stamps for micro-molding hydrogels. The authors developed a rapid and automated method for large scale on-demand micro-patterning of gelatin hydrogels for organ-on-chip applications using a novel biocompatible laser-etching approach.
Fourth of July Holiday Wishes and Closure Notice
Please note that UCT will be closed on Monday July 4th, 2016 in observance of Independence Day. We will reopen Tuesday, July 5th at 8 am EST.
We wish all of our clients a very happy and safe 4th of July holiday.
UCT SPE Cartridges cited in Equine Toxicology Study
In the fields of both human and animal toxicology, UCT Inc., is world renowned for its manufacture of the finest SPE sorbents. This is most eloquently demonstrated in an article published in Journal of Veterinary Pharmacology and Therapeutics ((2016) 39, 469–477) by H.K. Knych et al., (UCSF, Davis) detailing the pharmacokinetics of methocarbamol and phenylbutazone in exercised thoroughbred horses. Methocarbamol (MCBL) commonly used in performance horses for the treatment of skeletal muscle and phenylbutazone (PBZ), another commonly used drug in performance horses, were both extracted and analyzed using UCT’s flagship sorbent Clean Screen®DAU (CSDAU 130 mg/3 mL). This paper shows that when researchers working in the area of equine toxicology need the finest SPE sorbents for their extractions, they routinely turn to UCT as their first choice.